Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vitro, TWEAK enhances the expressions of IL-17, IL-18 and IFN-γ in keratinocytes under atopic dermatitis-like inflammation.
|
31515807 |
2020 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that autologous ADSCs improved DNCB-induced AD-like skin lesions in NC/Nga mice by reducing inflammation associated with Th2 immune response and interferon-γ.
|
30688372 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both AD cohorts showed similarly robust up-regulation of Th2-related (CCL17/18/26) and Th22-related markers (interleukin [IL]-22, S100A8/9/12), but AA AD featured decreased expression of innate immune (tumor necrosis factor [TNF], IL-1β), Th1-related (interferon gamma [IFN-γ], MX1, IL-12RB1), and Th17-related markers (IL-23p19, IL-36G, CXCL1) vs EA AD (P < .05).
|
30223113 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human keratinocyte (HaCaT) cells were stimulated with tumor necrosis factor alpha (TNF-α)/IFN-γ to induce AD-like keratinocyte environment.
|
31338033 |
2019 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, treatment with JC3 (10 mg/kg) significantly decreased serum and ear tissues levels of IFN-γ and IL-4 in AD mice.
|
30729380 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate and characterise the therapeutic effects of human Wharton's jelly-derived MSCs (WJ-MSCs) primed with the Toll-like receptor 3 agonist poly I:C or interferon-γ (IFN-γ) in a murine model of AD.
|
30795812 |
2019 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased levels of IFN-γ (Th1) and IL-17 (Th17), IL-4 and IL-13 (Th2) were detected in T cells and the skin tissue from the MSC-Ex treated AD mice.
|
31036853 |
2019 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
An opposite effect was detected upon IFN-γ production in TCD4 cells, such that AD IgG reduced IFN-γ production compared to production under mock conditions but not under IVIG conditions.
|
29355930 |
2018 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), IL-1β, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model.
|
29353040 |
2018 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, the lactobacilli isolated from <i>Jeotgal</i> may suppress the development of AD-like skin inflammation in mice by modulating IL-4 and IFN-γ production in CD4<sup>+</sup> T cells, presumably via enhancing IL-12 production by macrophages.
|
28672978 |
2017 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AD-MSCs showed an upregulation of many Th1/Th17 cytokines [interleukin (IL)-6, IL-8, IL-12, IL-13, IL-17A, IL-17F, transforming growth factor-β, interferon-γ], while Th2 chemokines (IL-2, IL-4, IL-5, IL-23A) were downregulated in AD-MSCs.
|
27639070 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon gamma (IFN-γ) has been used treat severe atopic dermatitis, with equivocal results.
|
29144049 |
2017 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the AD group, the levels of IL-18, IL-4, and IFN-γ in lymphocyte cultures with SEB were significantly increased compared with non-SEB exposed cells (each p<0.001); similar results were found in the control group.
|
27543731 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increases of general inflammatory (IL-2), innate (IL-1β), and some T<sub>H</sub>1/interferon (IFN-γ) markers in patients with ichthyosis were comparable with those in patients with psoriasis or AD.
|
27554821 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluorescence‑activated cell sorting demonstrated that the population of CD4+/IL‑4+, CD4+/IFN‑γ+ and CD4+/IL‑17A+ cells in draining lymph nodes was also significantly decreased in AXE‑treated mice compared with AD mice without AXE treatment.
|
28990098 |
2017 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the effects of DHE-Glc, a synthetic molecule derived from ergosterol, on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice and to elucidate the effects of DHE-Glc on TNF-α/IFN-γ-induced production of CCL17 and CCL22 in human keratinocytes (HaCaTs) and DNCB induced skin inflammation mice model.
|
26100037 |
2015 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β.
|
24996260 |
2014 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that IFN-γ decreases CERs with long-chain FAs through the downregulation of ELOVL and CerS and that this mechanism may be involved in the CER profile alteration observed in psoriasis and AD.
|
24008422 |
2014 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that CG inhibited the development of the AD-like skin symptoms by modulating Th1 and Th2 responses in the skin lesions in mice and TARC expression by suppressing TNF-α/IFN-γ-induced NF-κB activation in keratinocytes, and so may be a useful tool in the therapy of AD-like skin symptoms.
|
23454147 |
2013 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we aimed to investigate whether pCpG-Muγ, a plasmid continuously expressing murine IFN-γ, is an effective treatment of atopic dermatitis, a Th2-dominant skin disease.
|
22914497 |
2013 |
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Breast milk of the mothers of the children who developed atopic dermatitis had lower levels of IFN-γ (p = 0.039) as compared to the breast milk of the mothers of the children without dermatitis.
|
23980846 |
2013 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment of GCSE significantly reduced IgE production and expression of AD associated pathogenic cytokines such as IL-4, IL-5, IL-10, IL-13, IL-17, TNF-α, and IFN-γ by lymphocytes isolated from AD-induced mice.
|
24499290 |
2013 |
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Eight IRF2 SNPs were significantly associated with IFN-γ production after herpes simplex virus (HSV) stimulation (P = 0.048-0.0008), including an AD-associated SNP (rs13139310, P = 0.008).
|
22113474 |
2012 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate that keratinocytes of patients with AD exhibit increased IFN-γ-induced apoptosis compared with keratinocytes from healthy subjects.
|
22445417 |
2012 |
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
T cells from HCs reacted with different IL-4 and IFN-γ secretions to CRH treatment, whereas T cells from patients with AD did not.
|
22000570 |
2012 |