Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The STAT1, ALB, IL10, IL2, IL4, IL17A, TGFB1, IL1B, IL6, TNF, IFNG hub genes were particularly indicated to have significant roles in CD.
|
31809599 |
2020 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Early elevations of IL-2, IL-17A, IL-22 and IFN-γ after gluten in patients with coeliac disease implicates rapidly activated T cells as their probable source.
|
31505020 |
2020 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Selected biomarkers were able to classify subjects with clear CD/non-CD status, and a subset of the biomarkers (CXCL10, GBP5, IFI27, IFNG, and UBD) showed differential expression in biopsies from subjects with no or low-grade intestinal injury that received a CD diagnosis based on biopsies taken at a later time point.
|
30097691 |
2018 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mean serum levels of IFN-γ (p = 0.04) and IL-6 (p = 0.007) were significantly different between the patients in the CD and control groups, and IL-8 was significantly higher in the CD group compared with patients in the NCGS group (p = 0.04).
|
30240467 |
2018 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-18 and IFN-γ have also been implicated in the onset of different types of immune-mediate inflammatory conditions such as Type 1 Diabetes (T1D), Celiac disease (CD), rheumatoid arthritis (RA), obesity and systemic lupus erythematosus (SLE).
|
28673589 |
2017 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokine interferon-γ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease.
|
27936497 |
2017 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ten of the twenty-three peptides assayed recalled IFN-γ responses mediated by CD8<sup>+</sup> T cells in A*0101/B*0801<sup>+</sup> patients with CD.
|
28148736 |
2017 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mucosal molecular pattern of tissue transglutaminase and interferon gamma in suspected seronegative celiac disease at marsh 1 and 0 stages.
|
26655133 |
2016 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The dental pulp plays a pivotal role in the immune defence against possible entry of pathogens from teeth, and the aim of this work was to investigate quantitative transcription levels of selected genes (IL-9, IL-11, IL-15, IL-18, IL-21, IL-27, MICA, IFN-γ) coding for pro-inflammatory immune innate activities in the pulp of primary teeth from healthy children and children with coeliac disease.
|
26440733 |
2016 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation.
|
26444573 |
2015 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also discovered an intricate transcriptional connectivity between CD susceptibility genes and interferon-γ, a key effector in CD, despite the absence of CD-associated SNPs in the IFNG locus.
|
25190711 |
2015 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aims of this study were to ascertain whether five SNPs in the TNFA promoter (-1031T>C,-857C>T,-376G>A,-308G>A,-238G>A), sequence variants of the TNFRSF1A gene and IFNG +874A>T polymorphism are associated with CD in a HLA independent manner.
|
25915602 |
2015 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Children with untreated and GFD-treated CD had elevated expression of IFN-γ but had reduced expression of CD247.
|
24325470 |
2014 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin (IL)-15, IL-21 and interferon-γ, cytokines over-produced in active CD, inhibited the expression of TSP-1, CD36, and CD61 in normal intestinal LPMC.
|
24971453 |
2014 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
T cell lines specific for tTG and composed predominantly of CD4-positive T cells were generated from responsive CD and control individuals, and were found to produce large amounts of interferon-γ, as well as interleukins 10, 17A, and 21.
|
25131137 |
2014 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In coeliac disease (CD), the upper bowel lesion is associated with a marked infiltration of the mucosa with Th1 cells secreting interferon gamma (IFNgamma) and expressing the Th1-associated transcription factor, T-bet.
|
17965065 |
2008 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Anti-IL-15 antibody and c-jun antisense both downmodulated phospho-c-jun expression and restored TGF-beta-Smad-dependent transcription in biopsies of active celiac disease. c-jun antisense decreased interferon gamma transcription.
|
17324400 |
2007 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study, which provides evidence that the effect of G on iNOS gene transcription in IFN-gamma-stimulated RAW 264.7 cells can be ascribed to all three transcription factors, may contribute to lead to new insights into the molecular mechanisms governing the inflammatory process in celiac disease.
|
16284791 |
2006 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The downstream modulator of interferon-gamma, STAT1 is not genetically associated to the Dutch coeliac disease population.
|
16773129 |
2006 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Subjects positive for -308A tumour necrosis factor alpha and +874T interferon gamma alleles have an increased risk for coeliac disease.
|
15979955 |
2005 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Short term T cell lines (TCLs) obtained from treated CD biopsies cultured with gliadin with or without rhIL-10 were analysed by ELISPOT for gliadin specific production of IFN-gamma.
|
15591503 |
2005 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest a possible role of IFNgamma CA polymorphism in CD susceptibility.
|
15215891 |
2004 |
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In order to determine whether MICA is activated in response to gliadin in patients with celiac disease (CD), small intestinal mucosa biopsy samples from ten long-standing celiac patients on a gluten-free diet and from five non-celiac individuals were incubated with and without gliadin for 4 h. Total RNA was purified and MICA, IFNG and NKG2D mRNA were quantified by fluorescent real-time RT-PCR.
|
15490153 |
2004 |
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The interferon gamma gene in celiac disease: augmented expression correlates with tissue damage but no evidence for genetic susceptibility.
|
15324937 |
2004 |
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Th1 immune response, with a key position for interferon gamma (IFN-gamma), is an important determinant of intestinal remodeling in CD.
|
15324937 |
2004 |