The in vitro-generated MCs required not only IL-3 but also IFN-γ, and treatment of FA-induced mice with anti-IFN-γ antibody suppressed expansion of MCs in spleen as well as diarrhea development, highlighting that IFN-γ in the spleen orchestrated the development of FA, which was followed by a Th2 response in the local lesion.
Furthermore, supplementing POS in diets could alleviate diarrhea and decreased growth performance in the weaned pigs orally infused by PRV (P < 0.05), increase serum, jejunal, and ileal rotavirus antibody levels (P < 0.05) and attenuate the effect of PRV challenge on serum T-AOC and concentrations of IgG and MDA (P < 0.05), lipase and tryptase activities in jejunal digesta (P < 0.05), and sIgA, IL-4, and IFN-γ levels in jejunal and/or ileal mucosa (P < 0.05) in the weaned pigs.