Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
The interleukin (IL)-12/interferon(IFN)γ axis plays an important role in the control of mycobacterial diseases as demonstrated by the increased susceptibility to mycobacterial species in patients with an inborn error of the IL-12-dependent IFNγ immunity.
|
31741236 |
2019 |
Mycobacterium Infections
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The structure reveals the mechanism underlying deficits in IFNγ responsiveness in mycobacterial disease syndrome resulting from a T168N mutation in IFNγR2, which impairs assembly of the full signalling complex.
|
30814731 |
2019 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Mycobacterial infections are characteristic of defects in the interleukin (IL) 12/interferon γ pathway.
|
31690396 |
2019 |
Mycobacterium Infections
|
0.300 |
AlteredExpression
|
group |
BEFREE |
We found low levels of IFN-γ production and failure to respond to IL12 in 13 Iranian MSMD patients.
|
30715640 |
2019 |
Mycobacterium Infections
|
0.300 |
AlteredExpression
|
group |
BEFREE |
MSTs expanded from patients with primary immunodeficiency (PID) and invasive mycobacterial infections showed activity against mycobacterial antigens in only two of seven subjects, whereas both patients with IFN-γ autoantibodies recognized mycobacterial antigens.
|
30984189 |
2019 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Deficiency of the AIM2-ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection.
|
29255077 |
2018 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
We evaluated the IFN-γ circuit by studying IFN-γ production after mycobacterial challenge as well as IL-12Rβ1 expression and STAT4 phosphorylation in response to IL-12p70 stimulation in whole blood of a 6-year-old Peruvian girl with disseminated recurrent mycobacterial infection diagnosed as multidrug-resistant tuberculosis.
|
30039354 |
2018 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Human inborn errors of IFN-γ immunity underlie mycobacterial diseases.
|
30127434 |
2018 |
Mycobacterium Infections
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Laboratory evaluation of the IFN-γ circuit for the molecular diagnosis of Mendelian susceptibility to mycobacterial disease.
|
29502462 |
2018 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Interferon-γ (Interferon gamma, IFNG) is an important cytokine involved in providing resistance to mycobacterial diseases.
|
28881572 |
2017 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Factors associated with acquired Anti IFN- γ autoantibody in patients with nontuberculous mycobacterial infection.
|
28437431 |
2017 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Interferon-γ (IFN-γ) plays a crucial role in resistance to mycobacterial diseases; accordingly, variants of the gene encoding this cytokine may be associated with elevated risk of contracting pulmonary tuberculosis (TB).
|
28562756 |
2017 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Repurposing QuantiFERON for Detection of Neutralizing Interferon-γ Autoantibodies in Patients With Nontuberculous Mycobacterial Infections.
|
28430999 |
2017 |
Mycobacterium Infections
|
0.300 |
GeneticVariation
|
group |
BEFREE |
This case highlights the risk of mycobacterial infections with the use of various biologic agents and the need for caution when interpreting the results of interferon gamma release assays.
|
28317629 |
2017 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Identification of a major epitope by anti-interferon-γ autoantibodies in patients with mycobacterial disease.
|
27525523 |
2016 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Significant associations between mycobacterial infection and TNF-α production after stimulating peripheral blood mononuclear cells with LPS alone and with IFN-γ plus LPS were identified.
|
27686649 |
2016 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection.
|
26733044 |
2016 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Interferon-gamma (IFN-γ) and P2X7 receptor are crucial for host defence against mycobacterial infections.
|
27020872 |
2016 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Human inborn errors of immunity mediated by the cytokines interleukin-17A and interleukin-17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ (IFN-γ) immunity underlie mycobacterial disease.
|
26160376 |
2015 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
Patient had recurrence of mycobacterial disease during antibiotic therapy for which subcutaneous IFN-γ was added as a modality of treatment for resistant MAC infection.
|
26054576 |
2015 |
Mycobacterium Infections
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy.
|
24389160 |
2014 |
Mycobacterium Infections
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.
|
25453225 |
2014 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
ISG15 regulates IFN-γ immunity in human mycobacterial disease.
|
22964713 |
2013 |
Mycobacterium Infections
|
0.300 |
AlteredExpression
|
group |
BEFREE |
We report here a patient (P1) with MSMD whose cells display mildly impaired responses to IFN-γ, at levels, however, similar to those from MSMD patients with autosomal recessive (AR) partial IFN-γR2 or STAT1 deficiency.
|
23161749 |
2013 |
Mycobacterium Infections
|
0.300 |
Biomarker
|
group |
BEFREE |
In the patients' cells, the allele is dominant-negative for γ-activated factor-mediated responses to interferon-γ, but not for interferon-stimulated gene factor-3-mediated responses to interferon-α/β, accounting for the clinical phenotype of Mendelian susceptibility to mycobacterial diseases without severe viral diseases.
|
23585529 |
2013 |