|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IFN-γ release responses to Rv1986-P9, P15, P16, Rv1988-P4, P11, and Rv1987-P11 were significantly higher in the active TB group than in the control groups (p<0.05).
|
30528601 |
2020 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon gamma (IFN-γ) values in response to TB antigen and mitogen were significantly higher in children than in adults (TB antigen, median of 10 versus 1.66 IU IFN-γ/ml; mitogen, median of 10 versus 6.70 IU IFN-γ/ml; <i>P</i> < 0.0001).
|
31391228 |
2019 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.
|
31138395 |
2019 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, interleukin-18 (IL-18), an inducer of interferon-gamma (IFN-γ), playing an important role in anti-mycobacterial immune responses, may influence the risk of developing active tuberculosis (TB).
|
31301271 |
2019 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Complex co-expression of serum IL-18BP and IL-37, IP-10 and IFN-γ was identified as the highest discriminative biomarker set for the diagnosis of ATB.
|
31821340 |
2019 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis.
|
31388072 |
2019 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study evaluated the diagnostic performances of the IFN-γ and TNF-α dual release fluorospot assay for active TB.
|
31730906 |
2019 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two interferon gamma release assays for predicting active tuberculosis: the UK PREDICT TB prognostic test study.
|
30334521 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These persons do not exhibit adaptive immune priming as measured by tuberculin skin test (TST) and interferon-γ (IFN-γ) release assay (IGRA) responses, nor do they develop active tuberculosis (TB).
|
30487797 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results suggest that the ultra-sensitive SiMoA IFNγ assay could represent a useful tool for the identification of true positive and negative samples among those giving indeterminate or uncertain results with the TB IGRA assay currently used.
|
30714575 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Screening for TB was performed in children in asylum seeker reception centres by tuberculin skin test (TST) or interferon gamma release assay (IGRA).
|
29589578 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, Mtb-specific IFN-γ-producing T cells do not distinguish active tuberculosis (ATB) patients from individuals with asymptomatic latent Mtb infection (LTBI).
|
29983703 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Currently available interferon-γ release assays (IGRAs) are inadequate to diagnose active TB, with reported pooled sensitivity and specificity both under 81%.
|
30205963 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combined IFN-γ and TNF-α release assay for differentiating active tuberculosis from latent tuberculosis infection.
|
29746954 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result.
|
30151410 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Peripheral blood mononuclear cells from subjects with latent MTB infection (<i>n</i> = 16) and aTB (<i>n</i> = 39) at baseline, weeks 9, 12, and 26 (end of treatment) were analyzed after intracellular interferon gamma staining and overnight stimulation with tuberculin.
|
30323818 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, IFNG- and TNFA-expressing CD4+ T cells (Th1 cells) were more frequent in active TB than in LTBI, a difference that is undetectable with conventional, protein-based cytokine assays.
|
30283456 |
2018 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
M. tb heparin-binding-hemagglutinin (HBHA) induces relatively high IFN-γ responses in LTBI individuals and low responses in ATB patients, but purification of the native methylated HBHA from cultures of M. tb for immunological tests is complex and time-consuming.
|
28429162 |
2017 |
|
Active tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We derived a new equation to include interferon-γ (IFN-γ) levels in the QuantiFERON-Gold In-Tube (QFT-GIT) assay to discriminate active tuberculosis (ATB) infection from latent TB, and compared the diagnostic performance of the QFT-GIT assay and the new equation.
|
28398535 |
2017 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis.
|
28274215 |
2017 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In patients with positive ELISpot in pleural fluid (n = 16), the PPV for TB was 85.7%, which increased to 91.7% for the ESAT-6 panel and 92.3% for the CFP-10 panel after the introduction of a cut-off >1.0 for the ratio between the pleural fluid and blood interferon-gamma responses.
|
28024452 |
2017 |
|
Active tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum MIF, IFN-γ and TNF-α profiles distinguish tuberculosis from the more inflammatory phenotype and may play a role in pathogenesis and as biomarkers of active tuberculosis.
|
26542751 |
2016 |
|
Active tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In healthy household contacts (HHC), all the tested antigens induced significantly higher levels of IFN-γ and Interlukin-8 (IL-8) compared with those in PTB.
|
26546406 |
2015 |
|
Active tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The greatest diagnostic accuracy in discriminating active TB vs. LTBI or cured TB was reached by evaluating the CD27(+) CD45RA(-) cells within the IFN-γ⁺ CD4⁺ T-cell subset (76.92 sensitivity for both, and 90% and 91.67% specificity, respectively), although the use of the CD27 MFI RATIO allows for stricter data analysis, independent of the operator.
|
26253021 |
2015 |
|
Active tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Whereas M. tuberculosis-specific IFN-γ expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN-γ expression in TB patients.
|
24981709 |
2014 |