Enhanced cytotoxicity was not mediated by perforin, tumor necrosis factor-α, or tumor necrosis-associated apoptosis-inducing ligand but was closely associated with elevated interferon-γ in the tumor-bearing liver.
In our study, proinflammation capacity of P. acnes was confirmed by increased levels of various inflammatory modulators, such as interleukin (IL)-1β, IL-6, IL-12, monocyte chemoattractant protein-1, interferon-γ, and tumor necrosis facto-α, both in vivo and in vitro.
CNHK300-mIFN-gamma induced regression of xenografts in liver cancer models in both immunodeficient and immunocompetent mice by triplex mechanisms including selective oncolysis, antiangiogenesis, and immune responses.