IFNG, interferon gamma, 3458

N. diseases: 1519; N. variants: 11
Disease: Congenital atresia of extrahepatic bile duct ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4520983
Disease: Congenital atresia of extrahepatic bile duct
Congenital atresia of extrahepatic bile duct 		0.060 Biomarker disease BEFREE MicroRNA-29b/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-γ gene. 29748604 2018
CUI: C4520983
Disease: Congenital atresia of extrahepatic bile duct
Congenital atresia of extrahepatic bile duct 		0.060 AlteredExpression disease BEFREE Hepatic mRNA levels of interferon-gamma or interleukin-4 showed no significant differences between BA and non-BA, while FoxP3 was significantly higher in BA (<i>p</i> = 0.01). 27636194 2017
CUI: C4520983
Disease: Congenital atresia of extrahepatic bile duct
Congenital atresia of extrahepatic bile duct 		0.060 AlteredExpression disease BEFREE IFN-γ mRNA expression levels in BA patients were also significantly increased, and the IFN-γ gene promoter region was hypomethylated in BA CD4+ T cells compared with controls and negatively correlated with DNA methylation. 21857377 2011
CUI: C4520983
Disease: Congenital atresia of extrahepatic bile duct
Congenital atresia of extrahepatic bile duct 		0.060 GeneticVariation disease BEFREE Polymorphisms of the IFNG gene do not appear to play a major role in the genetic predisposition to BA in Taiwanese children. 19756986 2010
CUI: C4520983
Disease: Congenital atresia of extrahepatic bile duct
Congenital atresia of extrahepatic bile duct 		0.060 Biomarker disease BEFREE In the first, we interrogated the hepatic transcriptome of children with biliary atresia and found an interferon-gamma (IFNgamma)-rich proinflammatory footprint at the time of diagnosis. 16819397 2006
CUI: C4520983
Disease: Congenital atresia of extrahepatic bile duct
Congenital atresia of extrahepatic bile duct 		0.060 Biomarker disease BEFREE These findings were associated with production of interferon gamma in 65% of infants with biliary atresia and no diseased control. 12457789 2002