Insulin-Like Growth Factor I Deficiency
|
0.800 |
Biomarker
|
disease |
BEFREE |
The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency.
|
18359741 |
2008 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms identified in the upstream core polyadenylation signal at IGF1 exon 6 do not cause IGF1 deficiency as well as pre- and postnatal growth impairment, in contrast to previously reported data.
|
17895313 |
2007 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency.
|
14684690 |
2003 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
GermlineCausalMutation
|
disease |
ORPHANET |
A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency.
|
14684690 |
2003 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We have recently reported a patient with a homozygous partial deletion of the insulin-like growth factor-I (IGF-I) gene, resulting in IGF-I deficiency, insulin resistance, and short stature.
|
10770174 |
2000 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
Biomarker
|
disease |
BEFREE |
IGF-I deficiency is associated with prenatal and post-natal growth failure and may arise primarily as a result of GH receptor/post-receptor abnormalities or defects in the synthesis and transport of IGF-I.
|
10549306 |
1999 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
GermlineCausalMutation
|
disease |
ORPHANET |
Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
|
8857020 |
1996 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
|
8857020 |
1996 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
Biomarker
|
disease |
BEFREE |
The recent biosynthesis of insulin-like growth factor I has enabled the successful treatment of these patients, accelerating their growth, reducing their obesity, and normalizing their metabolic abnormalities resultant from the insulin-like growth factor I deficiency.
|
8374676 |
1993 |
Insulin-Like Growth Factor I Deficiency
|
0.800 |
Biomarker
|
disease |
CTD_human |
|
|
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Patients with ER+, IGF-1R-positive breast cancer without p-IGF-1R/InsR staining (n = 242) had tamoxifen benefit (HR 0.41, p = 0.0038), while the results for p-IGF-1R/InsR-positive patients (n = 125) were not significant (HR 0.95, p = 0.3).
|
31490549 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension was positively predicted by a BMI ≥ 30 kg/m<sup>2</sup> (HR 2.64, p 0.00) and IGF-I SDS values (HR 2.26, p 0.00).
|
31440920 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We sought to examine the effects of a 12-week resistance band exercise training program on aging-related hormones including estradiol, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and dehydroepiandrosterone sulfate (DHEA-S), BP, and body composition in postmenopausal women with stage 1 hypertension.
|
31663986 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Based on the findings from experimental and clinical studies, we propose that these lines of evidence converge, and suggest that age-related declines in IGF-1 concentrations precede microvascular rarefaction, initiate an increase in vascular resistance, and therefore are causally linked to onset of hypertension.
|
31808026 |
2020 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells.
|
31771180 |
2019 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The regulation of IGF-1 expression by leptin in breast cancer cells is unclear.
|
30293548 |
2019 |
Malignant neoplasm of breast
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In other 60 clinical samples, methylation specific polymerase chain reaction (PCR) and reverse transcription quantitative PCR were applied for the methylation of HOXA4 and IGF1 genes in BC and adjacent non-cancerous tissues.
|
30203578 |
2019 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of Breast Cancer-Related Epitopes Targeting the IGF-1 Receptor in Chimeric Human Parvovirus B19 Virus-Like Particles.
|
31317318 |
2019 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
We showed that members of the IGF-1/IGFBP-4/PAPP-A axis and FSTL-3 may serve as surrogate markers in breast cancer.
|
30388235 |
2019 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Prior studies have found positive associations between circulating IGF-I and the IGF-I:IGFBP-3 ratio and breast cancer risk.
|
31337427 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension was the major risk factor associated with low IGF1 in RA and stroke.
|
31327319 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
This study aimed to investigate the effects of PCA administration on vascular endothelial function, mediated by insulin and insulin-like growth factor-1 (IGF-1), and antioxidant activities in aging hypertension.
|
30934575 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To determine the role of IGF-1 deficiency in pathological remodeling of middle cerebral arteries (MCAs), we compared alterations in vascular mechanics, morphology, and remodeling-related gene expression profile in mice with liver-specific knockdown of IGF-1 (Igf1f/f + TBG-Cre-AAV8) and control mice with or without hypertension induced by angiotensin-II treatment.
|
29931048 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Logistic regression analysis showed that there was a negative correlation between thyroid nodules and levels of 25(OH)D3, IGF-1, TT3, as well as a positive correlation with FBG, TC, TT4, and hypertension.
|
31077177 |
2019 |
Prostatic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
IGF-1 elevation led to the accumulation of FOXO3A in the cytosol of prostate tumor cells and downregulation of its target gene Bim, which resulted in the apoptosis inhibition and prostate cancer overgrowth.
|
31312023 |
2019 |