|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Besides its well-established role in pathology of CVD, it is also implicated in neurodegenerative diseases and recent new data on adipose-produced apoE point to a novel metabolic role for apoE in obesity.
|
29516132 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the current study, we employed a model of human apoE targeted replacement mice and HFD-induced obesity to study the potential link between E4 and IR, at rest and following a postprandial challenge.
|
29215310 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The best interaction model for predicting obesity risk by MDR analysis was the three factor model including POMC (C > T), MC4R (T > C) and APOE (Hha1) polymorphisms.
|
26226973 |
2016 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present study identified the E4 allele of the APOE gene as being significantly associated with obesity in the Saudi population (p = 0.0001).
|
28085496 |
2017 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Overall MetS risk varied by dietary pattern and obesity status, independently of APOE and CVD risk factors.
|
15761175 |
2005 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In contrast, peripherally expressed APOE3 is associated with a notable shift of substrate oxidation towards non-shivering thermogenesis in visceral WAT mitochondria, leading to resistance to obesity.
|
29154926 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, apo E gene locus influences not only the levels of certain lipoprotein variables during young adulthood, but also modulates the association between obesity and dyslipidemias.
|
11398147 |
2001 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We use our algorithm to characterize the effect of genetic markers and liver gene expression traits on mouse obesity related phenotypes, including weight, cholesterol, glucose, and free fatty acid levels, in an experiment previously used for discovery and validation of network connections: an F2 intercross between the C57BL/6 J and C3H/HeJ mouse strains, where apolipoprotein E is null on the background.
|
22471599 |
2012 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Obese men with the APOE4 genotype presented with higher levels of insulin and glucose than obese men in the other genotype groups.
|
14694215 |
2003 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Is there any association of apolipoprotein E gene polymorphism with obesity status and lipid profiles? Tehran Lipid and Glucose Study (TLGS).
|
22921891 |
2012 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice.
|
29577045 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetically obese (ob/ob) mice, but not hyperlipidemic mice deficient in apolipoprotein E (Apoe(-/-)), had significantly higher circulating levels of SAA than their littermate controls.
|
19286646 |
2009 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It is concluded that the genetic polymorphism of apoE modulates the effects of obesity on lipids and lipoproteins and that allele epsilon 4 increases the risk of obesity-induced hypertriglyceridemia.
|
3233779 |
1988 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs, CETP Ile405Val and APOE Cys112Arg, were associated with both the prevalence of low HDL-cholesterol level (Ile405Val P = < .0001; Cys112Arg P = 0.001) and with the prevalence of abdominal obesity (Ile405Val P = 0.007; Cys112Arg P = 0.007).
|
21767357 |
2011 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
Moreover, the dysregulation of genes such as CES1 and APOE seems to be associated with some physiopathological markers of insulin resistance and cardiovascular risk factors in obesity.
|
20975297 |
2010 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Synergistic Effects of APOE Genotype and Obesity on Alzheimer's Disease Risk.
|
30586872 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition to these well-documented functions, recent studies in experimental mouse models, as well as population studies, show that apolipoprotein E also plays an important role in the development of obesity and insulin resistance.
|
19754875 |
2009 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome.
|
28720344 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using apolipoprotein E knock-out (apoE<sup>-/-</sup>) mice on a high fat (HF) diet as an atherosclerotic obesity model, we demonstrated 1) microRNA-155 (miRNA-155, miR-155) is significantly up-regulated in the aortas of apoE<sup>-/-</sup> mice, and miR-155 deficiency in apoE<sup>-/-</sup> mice inhibits atherosclerosis; 2) apoE<sup>-/-</sup>/miR-155<sup>-/-</sup> (double knock-out (DKO)) mice show HF diet-induced obesity, adipocyte hypertrophy, and present with non-alcoholic fatty liver disease; 3) DKO mice demonstrate HF diet-induced elevations of plasma leptin, resistin, fed-state and fasting insulin and increased expression of adipogenic transcription factors but lack glucose intolerance and insulin resistance.
|
27856635 |
2017 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Whether APOE genotype might interact with obesity in females to regulate AD pathogenesis is unclear.
|
30509127 |
2019 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
We evaluated predictors including demographics, APOE, intellectual enrichment, midlife risk factors (physical inactivity, obesity, smoking, diabetes, hypertension, and dyslipidemia), and the total number of late-life cardiac and metabolic conditions.
|
28418521 |
2017 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Moreover, the dysregulation of genes such as CES1 and APOE seems to be associated with some physiopathological markers of insulin resistance and cardiovascular risk factors in obesity.
|
20975297 |
2010 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In genetic association studies adjusted for age, BMI SDS and sex, we identified significant associations for rs599839 near SORT1 with TC and LDL-C and for rs4420638 near APOE with TC and LDL-C. We performed Bayesian modelling of the combined lipid phenotype of HDL-C, LDL-C and TG to identify potentially causal polygenic effects on this multi-dimensional phenotype and considering obesity, age and sex as a-priori modulating factors.
|
26375028 |
2015 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate whether a 12-week worksite health promotion program shows different response of cardiovascular risk factors in subjects according to apolipoprotein E (Apo E) genotype and obesity level in 141 male Korean industrial workers.
|
19761888 |
2009 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|