|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the current study, we employed a model of human apoE targeted replacement mice and HFD-induced obesity to study the potential link between E4 and IR, at rest and following a postprandial challenge.
|
29215310 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Whether APOE genotype might interact with obesity in females to regulate AD pathogenesis is unclear.
|
30509127 |
2019 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Herein, we compare the m- and h-APOE multi-gene clusters, and then critically review the relevant history and approaches to developing a Tg mouse model to characterize APOE-dependent AD pathology, in combination with genetic (sex, age) and modifiable (e.g., inflammation, obesity) risk factors.
|
31150730 |
2019 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Besides its well-established role in pathology of CVD, it is also implicated in neurodegenerative diseases and recent new data on adipose-produced apoE point to a novel metabolic role for apoE in obesity.
|
29516132 |
2018 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In contrast, peripherally expressed APOE3 is associated with a notable shift of substrate oxidation towards non-shivering thermogenesis in visceral WAT mitochondria, leading to resistance to obesity.
|
29154926 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice.
|
29577045 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Synergistic Effects of APOE Genotype and Obesity on Alzheimer's Disease Risk.
|
30586872 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome.
|
28720344 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
We used cardiac biopsies from human diabetic (n=23) and nondiabetic patients (n=19), cultured rat cardiomyocytes, left ventricular tissue from apolipoprotein E-deficient mice with streptozotocin-induced diabetes mellitus (n=12-22), and ZSF1 (obese diabetic Zucker fatty/spontaneously hypertensive heart failure F1 hybrid) rats (n=5-6) and analyzed insulin-dependent signaling pathways that modulate titin phosphorylation.
|
29760016 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present study identified the E4 allele of the APOE gene as being significantly associated with obesity in the Saudi population (p = 0.0001).
|
28085496 |
2017 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using apolipoprotein E knock-out (apoE<sup>-/-</sup>) mice on a high fat (HF) diet as an atherosclerotic obesity model, we demonstrated 1) microRNA-155 (miRNA-155, miR-155) is significantly up-regulated in the aortas of apoE<sup>-/-</sup> mice, and miR-155 deficiency in apoE<sup>-/-</sup> mice inhibits atherosclerosis; 2) apoE<sup>-/-</sup>/miR-155<sup>-/-</sup> (double knock-out (DKO)) mice show HF diet-induced obesity, adipocyte hypertrophy, and present with non-alcoholic fatty liver disease; 3) DKO mice demonstrate HF diet-induced elevations of plasma leptin, resistin, fed-state and fasting insulin and increased expression of adipogenic transcription factors but lack glucose intolerance and insulin resistance.
|
27856635 |
2017 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
We evaluated predictors including demographics, APOE, intellectual enrichment, midlife risk factors (physical inactivity, obesity, smoking, diabetes, hypertension, and dyslipidemia), and the total number of late-life cardiac and metabolic conditions.
|
28418521 |
2017 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Body mass index (BMI) was used to define obesity at a baseline, and the APOE genotype was classified into an APOE ε4 carrier and non-carrier status.
|
27738971 |
2017 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The best interaction model for predicting obesity risk by MDR analysis was the three factor model including POMC (C > T), MC4R (T > C) and APOE (Hha1) polymorphisms.
|
26226973 |
2016 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In genetic association studies adjusted for age, BMI SDS and sex, we identified significant associations for rs599839 near SORT1 with TC and LDL-C and for rs4420638 near APOE with TC and LDL-C. We performed Bayesian modelling of the combined lipid phenotype of HDL-C, LDL-C and TG to identify potentially causal polygenic effects on this multi-dimensional phenotype and considering obesity, age and sex as a-priori modulating factors.
|
26375028 |
2015 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Compared with MCSA subjects, SAS participants were younger, less educated, and had lower frequency of vascular disease, APOE ɛ4 carriers and obesity.
|
26402765 |
2015 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children.
|
25968937 |
2014 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to determine whether relationships between obesity, as measured by waist-to-hip ratio (WHR), and cognition and brain structure were modified by the apolipoprotein epsilon 4 allele (apoE4).
|
21835633 |
2013 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Overweight/obesity may potentiate the genetic variants of the APOE4 and APOA5_'T' alleles on the risk of sHTG.
|
23178747 |
2013 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We use our algorithm to characterize the effect of genetic markers and liver gene expression traits on mouse obesity related phenotypes, including weight, cholesterol, glucose, and free fatty acid levels, in an experiment previously used for discovery and validation of network connections: an F2 intercross between the C57BL/6 J and C3H/HeJ mouse strains, where apolipoprotein E is null on the background.
|
22471599 |
2012 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Is there any association of apolipoprotein E gene polymorphism with obesity status and lipid profiles? Tehran Lipid and Glucose Study (TLGS).
|
22921891 |
2012 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
APOE4) or involved in pathologic processes contributing to the disorder, including inflammation, diabetes, obesity and cardiovascular disease.
|
22245343 |
2012 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs, CETP Ile405Val and APOE Cys112Arg, were associated with both the prevalence of low HDL-cholesterol level (Ile405Val P = < .0001; Cys112Arg P = 0.001) and with the prevalence of abdominal obesity (Ile405Val P = 0.007; Cys112Arg P = 0.007).
|
21767357 |
2011 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
The strength of the relation and the similarity of the results obtained for both tested indicators of obesity provide firm evidence that APOE plays an important role in obesity development in the Roma population.
|
21244662 |
2011 |