|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a randomly sampled cross-sectional study of 985 South Asian, Chinese, and European Canadians, three common isoforms of ApoE (E2, E3 and E4), plasma lipid concentrations and atherosclerosis of the carotid artery were measured.
|
18656198 |
2009 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among 1677 nondemented ARIC (Atherosclerosis Risk in Communities) participants (mean age=76±5 years; 40% men; 26% black) with 3-Tesla MRI scans at the fifth examination (2011-2013), we fit multinomial logistic regression models to quantify relationships of brain volumes (Alzheimer disease signature regions, total gray matter, frontal gray matter, and white matter hyperintensity volumes), infarct frequencies (lacunar, nonlacunar, and total), and apolipoprotein E (number of ε4 alleles) with CMB location (none, deep/mixed, or strictly lobar CMBs).
|
29018129 |
2017 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis.
|
7762561 |
1995 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function.
|
15142050 |
2004 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the effects of complete IL-25 deficiency or of a temporal IL-25 blockade on atherosclerosis development in apolipoprotein E-deficient (<i>Apoe</i><sup>-/-</sup>) mice.
|
29572351 |
2018 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We recently described that apolipoprotein E (ApoE) deficient mice with a mutation in the fibrillin-1 (Fbn1) gene (ApoE<sup>-/-</sup>Fbn1<sup>C1039G+/-</sup>) develop accelerated atherosclerosis, plaque rupture, myocardial infarction, cerebral hypoxia and sudden death.
|
31085310 |
2019 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clinical and autoptical studies have suggested a predisposing role of the allele E4 of apolipoprotein E (apoE) in the development of atherosclerosis and cardiovascular disease.
|
9012642 |
1997 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The molecular polymorphism displayed by apolipoprotein E (apoE, protein; APOE, gene) has been listed as a risk factor for susceptibility to various disorders, such as those associated with lipid metabolism and arteriosclerosis.
|
14763609 |
2003 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Beyond the known influence of ApoE polymorphisms on serum lipid profile, the pathogenesis of atherosclerosis, and the development of neurodegenerative disorders, ApoE also has a major role in the pathogenesis and progression of a variety of renal diseases, as well as in the atherosclerotic complications associated with them.
|
14750087 |
2004 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, apolipoprotein E3/2 heterozygosity may have a protective effect on the development of early atherosclerosis.
|
6882285 |
1983 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to investigate the influence of the APOE promoter (-491 A/T, -427 T/C and -219 G/T) and coding region (APOE epsilon2/epsilon3/epsilon4) polymorphisms in atherosclerosis disease by association and linkage disequilibrium analyses.
|
18219091 |
2008 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic <i>APOE*3-Leiden</i> (<i>E3L</i>) mice.
|
29401645 |
2018 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings support extension of the importance of the apoE4 allele beyond atherosclerosis and Alzheimer's disease to calcific AS.
|
14530190 |
2003 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study.
|
12774036 |
2003 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Risk for arteriosclerosis is modulated by the apolipoprotein E (apoE) allele.
|
11096027 |
2000 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since nuclear factor-κB (NF-κB) is a central regulator of inflammatory processes, we hypothesized that chronically enhanced hepatic NF-κB activation, through hepatocyte-specific expression of IκB kinase-β (IKKβ) (LIKK), will aggravate atherosclerosis development in APOE*3-Leiden (E3L) mice.
|
21798539 |
2012 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile.
|
24530308 |
2014 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Effects of Dimethyl Fumarate on Atherosclerosis in the Apolipoprotein E-Deficient Mouse Model with Streptozotocin-Induced Hyperglycemia Mediated By the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element (Nrf2/ARE) Signaling Pathway.
|
31645538 |
2019 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we evaluated the contribution of CD39 to atherogenesis in the apolipoprotein E-deficient (ApoE-deficient) mouse model of atherosclerosis.
|
26121751 |
2015 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A previous study showed that the omega-6 fatty acid, dihomo-γ-linolenic acid (DGLA), attenuated atherosclerosis in the apolipoprotein E deficient mouse model system.
|
31202985 |
2019 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to atherosclerosis in the carotid arteries.
|
11546879 |
2001 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The inheritance of specific apolipoprotein E allelles has been linked to atherosclerosis, Alzheimer disease, and, most recently, to the incidence of age-related macular degeneration.
|
11384575 |
2001 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.
|
17562993 |
2007 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To study the role of endothelial HIF-1α in atherosclerosis, deletion of the Hif1a gene was induced in ECs from apolipoprotein E knockout mice (EC-Hif1a(-/-)) by Tamoxifen injection.
|
26483345 |
2015 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
(-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.
|
29593532 |
2018 |