|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a randomly sampled cross-sectional study of 985 South Asian, Chinese, and European Canadians, three common isoforms of ApoE (E2, E3 and E4), plasma lipid concentrations and atherosclerosis of the carotid artery were measured.
|
18656198 |
2009 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice.
|
15920036 |
2005 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, treatment of atherosclerosis-prone apolipoprotein E-deficient mice with a CD137 agonist caused increased inflammation.
|
18285570 |
2008 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transgenic mice overexpressing human APOE*3Leiden are highly susceptible to diet-induced hyperlipoproteinemia and atherosclerosis due to a defect in hepatic uptake of remnant lipoproteins.
|
8696956 |
1996 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Type III hyperlipoproteinemia usually results from an inherited defect in the composition of apolipoprotein E and is associated with atherosclerosis.
|
16227109 |
2005 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the effect of SCFAs on hypertensive cardiac damage and atherosclerosis, wild-type NMRI or apolipoprotein E knockout-deficient mice received propionate (200 mmol/L) or control in the drinking water.
|
30586752 |
2019 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously shown that magnetic resonance microscopy (MRM) accurately quantifies atherosclerosis in Apolipoprotein E deficient (ApoE(-/-)) mice aged 36-84 weeks.
|
11996951 |
2002 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among 1677 nondemented ARIC (Atherosclerosis Risk in Communities) participants (mean age=76±5 years; 40% men; 26% black) with 3-Tesla MRI scans at the fifth examination (2011-2013), we fit multinomial logistic regression models to quantify relationships of brain volumes (Alzheimer disease signature regions, total gray matter, frontal gray matter, and white matter hyperintensity volumes), infarct frequencies (lacunar, nonlacunar, and total), and apolipoprotein E (number of ε4 alleles) with CMB location (none, deep/mixed, or strictly lobar CMBs).
|
29018129 |
2017 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The apolipoprotein E knockout (ApoE -/-) mouse model is well established for the study of terpenoids in the prevention of atherosclerosis.
|
31392210 |
2019 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.
|
14744975 |
2004 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Irrespective of sex, deletion of Fn-EDA reduces early atherosclerosis in apolipoprotein E-deficient (Apoe<sup>-/-</sup>) mice.
|
29326316 |
2018 |
|
Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, ApoE4+ women are more likely to have higher levels of subclinical atherosclerosis if their metabolic phenotype is poor compared with ApoE4+ women without poor metabolic profile and ApoE4- women.
|
31362877 |
2019 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to determine the effects of ATL and its receptor Fpr2 on atherosclerosis development and progression in apolipoprotein E deficient (ApoE<sup>-/-</sup> ) mice.
|
28071789 |
2017 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In animal models, interruption of the AGE-RAGE interaction reduces lesion size and plaque development and RAGE deficiency in a RAGE(-/-)/apolipoprotein E(-/-) double knockout mouse attenuates the development of atherosclerosis in diabetes.
|
19347338 |
2009 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, these <i>ApoE<sup>-/-</sup></i> pigs could be valuable large animal models for providing further insight into translational studies of atherosclerosis.
|
30305304 |
2018 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis.
|
23625977 |
2014 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A small number of proteins have been shown in vitro to be upregulated by cellular cholesterol loading, including apolipoprotein E (apoE) and the recently cloned HDL-binding protein (HBP), but only apoE has been shown to be upregulated in cholesterol-loaded cells in atherosclerosis.
|
9409201 |
1997 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic ablation of the germinal center reduced both autoimmunity and atherosclerosis, indicating that the immune response that follows loss of APOE is independent of atherosclerosis but nevertheless promotes plaque development.
|
29880490 |
2018 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis.
|
7762561 |
1995 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E gene and early age-related maculopathy: the Atherosclerosis Risk in Communities Study.
|
16406547 |
2006 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E deficient mice (ApoE-/-), a mouse model of atherosclerosis, and their wild-type (WT) counterparts were used to assess agonist-stimulated synthesis of prostacyclin (PGI<sub>2</sub>), inhibition of platelet aggregation ex vivo, and intra-platelet cAMP levels.
|
28704616 |
2017 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we tested the effects of long-term consumption of a specific multi-nutrient diet in two models for atherosclerosis and vascular risk factors in AD: the apolipoprotein ε4 (apoE4) and the apoE knockout (apoE ko) mice.
|
23832599 |
2014 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apo E-KO mice may have normal growth and development, but advanced atherosclerosis and xanthomatosis may indirectly reduce their life span.
|
11726538 |
2001 |
|
Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
APOE-knockout rabbits have recently been shown to generate hyperlipidemia with increased levels of cholesterol and triglycerides that mimic the symptoms of atherosclerosis in humans.
|
29099857 |
2017 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist prevents cardiovascular injury, we investigated the beneficial effects and mechanism of the GLP-1 analogue exenatide on stress-related vascular senescence and atherosclerosis in apolipoprotein E-deficient (ApoE<sup>-/-</sup>) mice fed a high-fat (HF) diet.
|
28734203 |
2017 |