APOE, apolipoprotein E, 348

N. diseases: 1049; N. variants: 62
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Subgroup analysis revealed that APOE ε4, 2 alleles were not associated with an increased risk of MS in Caucasian population (OR(c-ε4)=0.924, 95% CI=0.819-1.041; OR(c-ε2)=1.127, 95% CI=0.955-1.331). 21679970 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease. 7700274 1994
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Apolipoprotein E genotype does not influence the progression of multiple sclerosis. 14504972 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Inheritance of the apolipoprotein E (APOE) epsilon4 allele is associated with increased risk of Alzheimer disease, progression to disability in multiple sclerosis, and poor outcome after traumatic brain injury. 12810485 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE To investigate the association between apolipoprotein E (Apo E) genotype in multiple sclerosis (MS) and acute monosymptomatic optic neuritis (ON) in a genetically homogeneous population with a high frequency of the Apo epsilon4 allele. 16193886 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease LHGDN To investigate the association between apolipoprotein E (Apo E) genotype in multiple sclerosis (MS) and acute monosymptomatic optic neuritis (ON) in a genetically homogeneous population with a high frequency of the Apo epsilon4 allele. 16193886 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease LHGDN Studies examining the epsilon4 allele of the APOE gene as a factor affecting the severity of multiple sclerosis (MS) have yielded conflicting results. 17294608 2007
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Neuropsychological assessment, quantitative MRI and ApoE gene polymorphisms in a series of MS patients treated with IFN beta-1b. 16626758 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results. 19786693 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. 15007140 2004
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Given the large sample size of our analyses, it is unlikely that the two APOE missense SNPs studied here exert any relevant effects on MS susceptibility. 22972946 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Influence of APOE gene polymorphisms on interferon-beta treatment response in multiple sclerosis. 21163235 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE The purpose of the present study was to determine whether the ε4 allele of APOE is associated with more extensive brain pathology in MS using structural and diffusion tensor MRI. 21723395 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease LHGDN An analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease (P=.03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02). 11836653 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE We performed (1)H-MRS of the central portion of both hemispheres and APOE genotyping in 72 patients (52 women and 20 men; mean +/- SD age, 34.8 +/- 8.8 years) with clinically definite relapsing-remitting MS. 12533090 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE To resolve these discrepancies, we examined common sequence variation in six candidate genes residing in a 380-kb genomic region surrounding and including the APOE locus for an association with MS severity. 16738668 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. 15699400 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Results for the e4/e2 alleles of the ApoE gene as markers of susceptibility, clinical and radiological progression, and cognitive deterioration in patients with multiple sclerosis (MS) are contradictory. 21325856 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Our data suggest that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability. 19473356 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms. 17294608 2007
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE In summary, the present meta-analysis provides evidence that ApoE ε2 mutation is associated with MS risk. 22982410 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE No association of apolipoprotein E epsilon4 genotype with faster progression or less recovery of relapses in a Spanish cohort of multiple sclerosis. 16459715 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE The relationship between ApoE and MPO genes' polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. 15222689 2004
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Although the low rate of epsilon4 allele in Japan should be taken into consideration, our results showed no relation between APOE gene polymorphisms and Japanese patients with MS. 12926843 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.400 GeneticVariation disease BEFREE Pooled analyses of MS cases were also performed to assess the influence of APOE epsilon genotype on disease severity. 16682670 2006