Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we identified 5 (8.3%) LPVs and 18 (30%) VUSs in known dementia-related genes in apolipoprotein E ε4 noncarrying Korean patients with early-onset Alzheimer's disease.
|
31217084 |
2020 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In late-onset AD, elevated circulating cholesterol levels increase AD risk even after adjusting for the apolipoprotein E ε4 (APOE E4) allele, a major genetic factor for AD and elevated cholesterol levels; however, the role of circulating cholesterol levels in EOAD is unclear.
|
31135820 |
2019 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, or APP, APOE4 alleles, and rare variants within TREM2, SORL1, and ABCA7 contribute to early-onset Alzheimer's disease (EOAD).
|
31381512 |
2019 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
|
29107063 |
2018 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
|
30319691 |
2018 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
|
30320580 |
2018 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients.
|
27023435 |
2017 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease.
|
26714935 |
2016 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with EOAD.
|
26444786 |
2016 |
Alzheimer Disease, Early Onset
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.
|
27260402 |
2016 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
None of these patients had pathogenic mutations, APOE ε4 or other high-risk alleles associated with early-onset Alzheimer's disease.
|
26354483 |
2015 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Elevated serum pesticide levels and risk for Alzheimer disease.
|
24473795 |
2014 |
Alzheimer Disease, Early Onset
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
|
23571587 |
2013 |
Alzheimer Disease, Early Onset
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
|
23296339 |
2013 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
Alzheimer Disease, Early Onset
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.
|
23060451 |
2012 |
Alzheimer Disease, Early Onset
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis.
|
22381401 |
2012 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Retrospective review of clinical data (age at onset, family history, clinical presentation, diagnostic delay, diagnosis) and APOE genotype of patients with neuropathologically confirmed EOAD (<60 years).
|
21576687 |
2011 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes.
|
21185234 |
2011 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men.
|
20819998 |
2010 |
Alzheimer Disease, Early Onset
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.
|
19605830 |
2009 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
BEFREE |
Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset.
|
19335933 |
2009 |
Alzheimer Disease, Early Onset
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
|
19734902 |
2009 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the 13 SNPs in the SORL1 gene that had been studied in previous reports using case-control methods and included sex, apolipoprotein E (APOE) genotype, and age at AD onset as covariates.
|
19822782 |
2009 |
Alzheimer Disease, Early Onset
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ApoE4 allele frequency was significantly increased in the patients with eoAD and in those with FTLD.
|
19091059 |
2008 |