|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Since insulin-like growth factor 1 receptor (IGF1R) signaling and phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling have been shown to play a pivotal role in regulating osteogenesis, we hypothesized that the osteogenic activity of calycosin is mediated by these signaling pathways.
|
30632644 |
2019 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Lung adenocarcinoma cells harboring KRAS mutations have been shown previously to be selectively sensitive to inhibition of mitogen-activated protein kinase kinase (MEK) and insulin-like growth factor 1 receptor (IGF1R) signaling.
|
31534020 |
2019 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We also found elevated levels of phospho-IGF1R in our resistant Ewing cell line, supporting the relevance of IGF1R signaling to acquired resistance.
|
30397176 |
2019 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Grb10 (growth factor receptor-bound protein 10)-interacting GYF protein 1 (GIGYF1) can modulate insulin-like growth factor 1 receptor (IGF1R) signaling pathway, which plays an important role in regulating diabetes-associated cognitive impairment, by linking to Grb10 adapter.
|
30376373 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Aberrant insulin-like growth factor I receptor (IGF1R) signaling pathway serves as a well-established target for cancer drug therapy.
|
30195750 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
On the other hand, ezrin phosphorylation at Thr-567 by insulin-like growth factor 1 receptor (IGF1R) signaling leads to cAMP-dependent PKA activation and enhances cell survival.
|
29599290 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
We first generated the adenovirus that simultaneously expresses three human or mouse siRNAs targeting IGF1R (AdRIGF1R-OK). qRT-PCR and immunofluorescence staining revealed that IGF1R expression was significantly decreased in the melanoma cells that were infected with AdRIGF1R-OK. Bioluminescence imaging showed that the size of the tumor formed by the xenografts infected with AdRIGF1R-OK was significantly smaller than that of the controls.
|
30161025 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
ER+ ILC cell lines and xenograft tumor explant cultures were used to evaluate efficacy to IGF1R pathway inhibition in combination with endocrine therapy.<b>Results:</b> Diminished functional E-cadherin increased both activation of IGF1R signaling and efficacy to anti-IGF1R/InsR therapies.
|
29941485 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Sublines established from stroma-treated FR-cells (C-FR cells) and D-cells (C-D cells) show permanently high expression of integrin β1 as well as Bcl-3 and P-STAT3 (C-FR) or IGF1R (C-D).
|
29774124 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results were in contrast to those in the seminoma cell line TCAM2 that lacked IGF1R signalling via AKT and was one of the two cell lines least sensitive to the IGF1R inhibitor.
|
29160922 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A unique G310D variant in IGF1R, which occurs in 6% American Indians, may impair IGF1R signalling pathways, thereby increasing the risk of T2D.
|
29470850 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
The activation of IGF1R signaling was assessed by the phosphorylation of IGF1R and its downstream target AKT using immunoblot.
|
30089593 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought.
|
29530981 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Many investigations have implicated the insulin-like growth factor 1 receptor (IGF1R) signaling in maintenance of stem cell characteristics and enhancement of stem cell therapy efficacy.
|
29882416 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor 1 receptor (IGF1R) signaling is one of the factors in RA pathogenesis as well as a known regulator of adult neurogenesis.
|
30509997 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to explore whether insulin-like growth factor 1 receptor (IGF1R) signaling participated in regulating the proliferation of EPCs.
|
30184089 |
2018 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
It has been shown that G-protein-coupled receptor kinase 2 (GRK2) negatively regulates the insulin-like growth factor 1 receptor (IGF1R) signalling pathway in hepatocellular carcinoma (HCC).
|
28202495 |
2017 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Seminal studies using post-mortem brains of patients with Alzheimer's disease evidenced aberrant insulin-like growth factor 1 receptor (IGF1R) signalling.
|
28595357 |
2017 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interaction of DNA damage and inflammation is affected by the insulin-like growth factor 1 receptor (IGF1R) signaling pathway.
|
29290648 |
2017 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
To further understand IGF1R signaling we have investigated the involvement of the oncogenic IGF1R-related sphingosine kinase (SphK) pathway.
|
29207959 |
2017 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cotargeting IR/IGF1R and PDGFR decreased the emergence of resistant clones <i>in vitro</i> Our findings characterize a novel model of glioma recurrence that implicates the IR/IGF1R signaling axis in mediating the development of resistance to PDGFR inhibition and provide evidence that IR/IGF1R signaling is important in the recurrence of the proneural subtype of glioma in which PDGF/PDGFR is most commonly expressed at a high level.<i></i>.
|
28138037 |
2017 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Through co-immunoprecipitation and western blot assay, we confirmed that GRK2 can interact with insulin-like growth factor 1 receptor (IGF-1R) and inhibits IGF1-induced activation of IGF1R signaling pathway.
|
26936374 |
2016 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that activation of the insulin-like growth factor 1 receptor (IGF1R) signaling pathway contributes to afatinib resistance in NSCLC cells harboring the T790M mutation.
|
26052929 |
2016 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
This concern is especially true for insulin-like growth factor 1 receptor (IGF1R), because IGF1R signaling is downregulated by multiple AKT and mTOR feedback mechanisms.
|
25172964 |
2014 |
|
Resistance to Insulin-Like Growth Factor I
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inhibition of the IGF1R signaling pathway by humanized recombinant IGF1R monoclonal antibody MK-0646 in athymic mouse subcutaneous xenografts resulted in inhibition of p-ezrin T567 indicating ezrin signaling is downstream of the IGF1R signaling pathway.
|
24462708 |
2014 |