Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggest that the primary event in tumor-induced hypoglycemia is overproduction of IGF-II by the tumor, which gives rise to hypoglycemia by a dual mechanism: increased glucose utilization mediated by the insulin-like actions of IGF-II and inhibition of GH secretion.
|
2646313 |
1989 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The former comprised a greater proportion of total IGF-II, in patients with hypoglycemia.
|
2159026 |
1990 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that nonislet cell tumors associated with hypoglycemia produce large amounts of IGF-II mRNA and that this IGF-II mRNA appears to be the product of an IGF-II gene, which is apparently normal in the region encoding mature IGF-II peptide.
|
2584352 |
1989 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor-derived big IGF-II is responsible for enhanced insulin-like effects in the body through complicated mechanisms, leading to hypoglycemia.
|
26073062 |
2015 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the imprinting control and promoter usage for IGF2 expression to identify a mechanism for increased IGF-II production in non-islet-cell tumor hypoglycemia.
|
19383775 |
2009 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Also, it is known that insulin-like growth factor 2 is an etiology of non-islet cell tumor hypoglycemia.
|
28012446 |
2017 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High-molecular weight IGF-2 expression in a haemangiopericytoma associated with hypoglycaemia.
|
9236865 |
1997 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
All patients with endogenous hypoglycaemia related to inappropriate insulin or to IGF2 secretion between 2012 and 2016 and considered normoglycaemic with medical treatment (absence of clinical hypoglycaemia and self-monitoring blood glucose in the normal range) were enroled and underwent a six-day continuous glucose monitoring (CGM) recording.
|
30817011 |
2019 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous reports suggest a role for IGF2 over-expression in the pathogenesis of these tumours, implicated in triggering hypoglycaemia in some patients.
|
20527023 |
2010 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we showed that two patients without hypoglycemia also had a small amount of big IGF2 in their serum.
|
29897468 |
2018 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma.
|
10468998 |
1999 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.
|
3185662 |
1988 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the serum level of IGF binding protein-3 was low, whereas the serum insulin level and other endocrinological examinations were normal, we speculate that the mechanism of the hypoglycemia was associated with the tumor-produced IGF2.
|
8760024 |
1996 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
|
18552458 |
2008 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that 57% +/- 4.6% of the IGF-II in sera from patients with hypoglycemia was present as big IGF-II compared with 22% +/- 3% in patients with euglycemia with hepatomas (not significantly different from that in normal controls).
|
2170553 |
1990 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that a dysregulation of gene expression and imprinting of chromosome 11p15 region is associated with tumour growth and IGF-II overexpression in non-islet-cell tumour hypoglycaemia.
|
10931103 |
2000 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Non-islet cell hypoglycemia (NICH) is hypoglycemia due to the overproduction of insulin-like growth factor-2 (IGF-2) and its precursors which can activate the insulin receptor.
|
31156561 |
2019 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An insulin-like growth factor II-producing histiocytoma associated with hypoglycemia: analysis of the peptide, its gene expression, and glucose transporter isoforms.
|
1311795 |
1992 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In 25 of 28 patients with this type of hypoglycemia we found 1.5-8-fold elevated serum levels of immunoreactive big (15-25 kD), but decreased levels of normal IGF II.
|
1281841 |
1992 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is now convincing evidence that some tumors secrete sufficient IGF-II to have systemic endocrine effects as recognized as nonislet cell tumor hypoglycemia.
|
1718747 |
1991 |
Hypoglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Further evaluation revealed elevated IGF-II levels consistent with non-islet cell tumor-induced hypoglycemia.
|
31328061 |
2019 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We postulated that the pathogenesis of her hypoglycemia involved production of IGF-II by her neuroblastoma, leading to GH suppression and an abnormally elevated ratio of IGF to IGF binding protein.
|
7658270 |
1995 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Solitary fibrous tumors occasionally present with hypoglycemia because of the excessive release of insulin-like growth factor II.
|
27585487 |
2016 |
Hypoglycemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.
|
3185662 |
1988 |