Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice with anti-IGF2 antibodies were partially protected against the metastatic growth of IGF2-addicted rhabdomyosarcoma cells.
|
30732578 |
2019 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, biallelic IGF2 expression has been linked to rhabdomyosarcoma tumorigenesis and pUPD11 occurred in all 8 ERMS samples from CS individuals.
|
26572961 |
2016 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report here that insulin-like growth factor 2-binding protein 1 (IGF2BP1), an oncofetal protein, is expressed in RMS patient-derived cell lines and in primary tumours where it drives translation of the cellular inhibitor of apoptosis 1 (cIAP1), a key regulator of the nuclear factor-κB signalling pathway and of caspase-8-mediated cell death.
|
24704827 |
2015 |
Childhood Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed that while both embryonal and alveolar rhabdomyosarcomas (ERMS and ARMS, respectively) show LOI of the DMR at the IGF2-H19 locus, imprinting of the DMR at the DLK1-GTL2 locus varies in association with the histological subtype of RMS.
|
24173021 |
2014 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In relation to the control reference samples (QPCR Human Reference Total RNA-Stratagene, Human Skeletal Muscle Total RNA-Ambion, Universal RNA Human Normal Tissues-Ambion), RMS samples showed a high IGF2 gene expression (p<0.0001).
|
24846856 |
2014 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, mRNA expression, assessed by real-time PCR, of MEST, PEG3, and IGF2 in rhabdomyosarcoma cell lines was increased as compared to nonembryonal cancer cell lines.
|
22289848 |
2012 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IGF2 overexpression was observed in 80% of samples and could indicate an important role of this pathway in RMS biology.
|
23079386 |
2012 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of RMS cell lines by real-time reverse transcriptase-polymerase chain reaction for IGF2 expression revealed significantly higher mean expression levels in ERMS and translocation-negative ARMS cell lines when compared to translocation-positive ARMS cell lines (P = 0.0027).
|
18788888 |
2009 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rhabdomyosarcoma (RMS) cell lines secrete high levels of insulin-like growth factor II (IGF-II), suggesting autocrine IGFs play a major role in the unregulated growth and metastasis of RMS.
|
12942549 |
2003 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of a rhabdomyosarcoma cell line which has a silent, methylated H19 gene with histone deacetylase (HDAC) inhibitors under conditions which gave maximal hyperacetylation of histone 4, both globally and at the H19 gene itself could not reactivate H19 or affect the active Insulin-like Growth Factor 2 (IGF2) gene, but caused clear up-regulation of the Tissue-type Plasminogen Activator (TPA) gene, a non-imprinted gene known to respond to changes in histone acetylation.
|
12234381 |
2002 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data together suggest that AP-2 may contribute to the high expression of IGF-II in rhabdomyosarcoma cells.
|
9771969 |
1998 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor II and PAX3-FKHR cooperate in the oncogenesis of rhabdomyosarcoma.
|
9766674 |
1998 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this report, we demonstrate that wild-type p53 expression in rhabdomyosarcoma cell lines containing mutant p53 leads to a decrease in the activity of another active IGFII promoter, P4, and a 5-fold reduction of IGFII mRNA derived from the P4 promoter.
|
9502429 |
1998 |
Childhood Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have previously reported that the number of functional IGF-2 alleles is frequently increased in rhabdomyosarcoma (RMS), as a consequence of either relaxation of imprinting (LOI) or gene duplication.
|
9136994 |
1997 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the imprinting of all IGFII promoters is relaxed in rhabdomyosarcoma and lung cancer.
|
7499276 |
1995 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously reported loss of imprinting (LOI) of IGF2 in rhabdomyosarcoma (RMS) where IGF2 has been shown to act as an autocrine growth factor and play an important role in pathogenesis.
|
8545106 |
1995 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since IGF-II has been indicated as an autocrine growth factor for rhabdomyosarcoma cells, these findings strongly suggest that acquisition of a double dosage of active IGF-II gene is an important step for the initiation or progression of rhabdomyosarcoma tumorigenesis.
|
7981680 |
1994 |
Childhood Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, embryonal RMS usually has loss of heterozygosity (LOH) with paternal disomy of the IGF2 locus.
|
8040287 |
1994 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Specific expression of insulin-like growth factor-II in rhabdomyosarcoma tumor cells.
|
8116575 |
1994 |
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biosynthesis of 10 kDa and 7.5 kDa insulin-like growth factor II in a human rhabdomyosarcoma cell line.
|
7686519 |
1993 |
Childhood Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization indicated that all RMSs showed highly strong and specific IGF-II mRNA expression, whereas other soft tissue tumors showed very low or no signal.
|
1434543 |
1992 |
Childhood Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, these analyses identify two syntenic clusters of muscle-associated genes on the short arm of human chromosome 11, one in the region of rhabdomyosarcoma locus that includes IGF2 and TH and the second the tightly linked MYOD1 and LDHA loci, which have been evolutionarily conserved in homologous regions of both the mouse and the rat genomes.
|
2315312 |
1990 |