IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Disease: Nephrogenic rest ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1320468
Disease: Nephrogenic rest
Nephrogenic rest 		0.020 GeneticVariation disease BEFREE By applying an allele-specific in situ hybridization technique to formalin-fixed thin sections, we show that the parental IGF2 alleles can be differentially expressed, not only in Wilms' tumors, but also in nephrogenic rests (which represent premalignant lesions) of Wilms' tumor patients. 10463576 1999
CUI: C1320468
Disease: Nephrogenic rest
Nephrogenic rest 		0.020 AlteredExpression disease BEFREE 2) The IGF-II expression in WTs and NRs does not simply reflect the embryonal nature of the tumor but is rather significantly altered, suggesting a role as a transforming growth factor in Wilms tumorigenesis. 7504120 1993