Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we observed that 91H, H19 and IGF2 are overexpressed in breast tumors.
|
27780718 |
2017 |
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Altered methylation of exonic CpG plays an important role in the enhanced transcription/expression of IGF2 in breast tumors.
|
20422427 |
2011 |
Mammary Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells.
|
18428028 |
2008 |
Mammary Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Elevated free IGF2 levels in localized, early-stage breast cancer in women.
|
18719053 |
2008 |
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells.
|
17369847 |
2007 |
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
Resveratrol regulates insulin-like growth factor-II in breast cancer cells.
|
16037384 |
2005 |
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis of IGF-II and ST-3 protein expression in sarcomas and breast tumors confirmed the mRNA data.
|
9177406 |
1997 |
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This suggests that IGF-II may have an important growth regulatory effect on breast tumor epithelium through paracrine pathways.
|
8932875 |
1996 |
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We examined 18 fresh-frozen (FF) breast tumors with their adjacent normal breast tissue and 14 sets of paraffin-embedded formalin-fixed tissues for IGF2 and H19 gene expression and imprinting.
|
8636375 |
1996 |
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IGF-II-negative stromal fibroblasts from normal breast, which were plated at low density and allowed to grow to confluence in the presence of MCF-7 breast tumor epithelial cells, demonstrated a marked increase in IGF-II mRNA expression.
|
7757999 |
1995 |
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similarly, IGF-II is expressed in breast tumors, predominantly in stromal cells, but sometimes also in carcinoma cells and in a subset of cell lines.
|
1651793 |
1991 |
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, both IGF-I and IGF-II mRNAs are easily detected in the majority of breast tumor specimens examined, while no breast cancer epithelial cell lines we have studied express authentic IGF-I mRNA, and few lines express IGF-II mRNA.
|
2152773 |
1990 |
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, IGF-II may function as an autocrine or a paracrine growth factor in different breast tumors.
|
3180080 |
1988 |