IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Disease: Perilobar nephroblastomatosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4551836
Disease: Perilobar nephroblastomatosis
Perilobar nephroblastomatosis 		0.030 Biomarker disease BEFREE Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors. 19047088 2008
CUI: C4551836
Disease: Perilobar nephroblastomatosis
Perilobar nephroblastomatosis 		0.030 GeneticVariation disease BEFREE Two distinct types of IGF2 LOI tumours were identified: the first type had a blastemal-predominant histology associated with PLNR, while the second subtype had a myogenic histology, increased expression of mesenchymal lineage genes and an association with ILNR, similar to WT1-mutant tumours. 18484682 2008
CUI: C4551836
Disease: Perilobar nephroblastomatosis
Perilobar nephroblastomatosis 		0.030 Biomarker disease BEFREE Our findings that IGF2 LOI and perilobar nephrogenic rests associated with this mechanism arise at low frequency in Japanese and east-Asian American children lend support to this conclusion. 14962525 2004