Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpressed insulin-like growth factor binding protein 2 (IGFBP2) promotes GBM cell migration and invasion, and contributes to glioma progression and cancer recurrence and poor survival in GBM.
|
31560714 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enforced expression of IGFBP2 increased network formation of glioma cells in vitro by activating CD144 and MMP2 (Matrix Metalloproteinase 2).
|
30368528 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGFBP2 re-emerges as a candidate biomarker and potential therapeutic target in glioma.
|
31296788 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that IGFBP2 expression was upregulated in high-grade glioma and GBM and downregulated in IDH mutant glioma.
|
29721393 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IGFBP2 expression predicts IDH-mutant glioma patient survival.
|
27852048 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We took advantage of the well-characterized RCAS/Ntv-a mouse model to create a doxycycline-inducible IGFBP2 model of glioma and demonstrated that the temporal expression of IGFBP2 has dramatic impacts on tumour progression and survival.
|
27125842 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These activities are also consistent with the strong association between IGFBP2 and STAT3-activated genes derived from The Cancer Genome Atlas database for human glioma.
|
25893308 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate for the first time that in vitro inhibition of extracellular IGFBP2 activity by using human scFv results in significant reduction of glioma cell migration and invasion.
|
25944386 |
2015 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results support a functional interaction between IGFBP2 and ADAMTS1 and suggest the need to evaluate post-translational modifications of IGFBP2 in glioma, in order to approach new therapies.
|
24962328 |
2014 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of IGFBP2 is associated with progression of tumors that include prostate, ovarian, glioma among others.
|
23767917 |
2013 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most significantly, the IGFBP2/integrin/ILK/NF-κB network functions as a physiologically active signaling pathway in vivo by driving glioma progression; interfering with any point in the pathway markedly inhibits progression.
|
22345562 |
2012 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate a generalized hypermethylation phenotype in glioma linked to improved survival and low IGFBP2.
|
21339190 |
2011 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Herein we demonstrate that IGFBP2 is overexpressed within the stem cell compartment of GBMs and is integral for the clonal expansion and proliferative properties of glioma stem cells (GSCs).
|
20515648 |
2010 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we examined the mechanism through which the IGFBP2/integrin alpha5 interaction mediates enhanced glioma cell migration.
|
20514406 |
2010 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of Ink4a-Arf results in increased IGFBP2, which contributes to glioma progression, thereby implicating IGFBP2 as a marker and potential therapeutic target for Ink4a-Arf-deleted gliomas.
|
19805356 |
2009 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IQGAP1 and IGFBP2: valuable biomarkers for determining prognosis in glioma patients.
|
17483698 |
2007 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, this study provides definitive evidence that IGFBP2 plays a key role in activation of the Akt pathway and collaborates with K-Ras or PDGFB in the development and progression of two major types of glioma.
|
17606927 |
2007 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Thus, this study provides definitive evidence that IGFBP2 plays a key role in activation of the Akt pathway and collaborates with K-Ras or PDGFB in the development and progression of two major types of glioma.
|
17606927 |
2007 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using an inducible PTEN expression system in the PTEN-null glioma cell line U251, we demonstrate that PTEN-induction is associated with reduced proliferation, increased apoptosis, and a substantial reduction of the high levels of IGFBP-2 expression.
|
16154532 |
2005 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data provide evidence that IGFBP2 contributes to glioma progression in part by enhancing MMP-2 gene transcription and in turn tumor cell invasion.
|
12907597 |
2003 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using gene expression microarray technology, the IGFBP2 gene was recently found to be highly and differentially overexpressed in the most advanced grade of human glioma, glioblastoma.
|
11770904 |
2002 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade.
|
11250947 |
2001 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of IGFBP2 as a gene associated with glioma progression demonstrates the power and utility of high-throughput gene expression profiling in cancer gene discovery.
|
10485462 |
1999 |