Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.340 PosttranslationalModification disease BEFREE To explore possible epigenetic changes of the IGFBP2 gene in obesity, we analyzed DNA methylation and mRNA expression in adipocytes from different depots. 30921666 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.340 GeneticVariation disease BEFREE In addition, the PPAR-γ2-RXR-α heterodimer showed weak activity and bound weakly to the putative IGFBP-2-PPRE promoter sequence in VAT from HIR-MO subjects when compared with LIR-MO individuals. 31547433 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.340 Biomarker disease BEFREE Secretion of IGFBP-1 and IGFBP-2 is further suppressed by insulin and diminished with increasing obesity. 26522454 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.340 Biomarker disease CTD_human Insulin-like growth factor binding protein-2 (IGFBP2) is a key regulator of IGF activity that has been associated with insulin resistance and obesity. 22537059 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.340 Biomarker disease BEFREE These findings demonstrate that the transcription of the IGFBP2 gene is modulated in a depot-specific fashion in obesity and aging in mice and men. 20730703 2010