|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGFBP2 promotes neural stem cell maintenance and proliferation differentially associated with glioblastoma subtypes.
|
30347220 |
2019 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(<i>Bioscience Reports</i> (2019), DOI:10.1042/BSR20190045) RNAscope was used to detect insulin-like growth factor binding protein 2 (<i>IGFBP2</i>) mRNA in glioblastoma biopsies.
|
31296788 |
2019 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of IGFBP2 mRNA predicts poor survival in patients with glioblastoma.
|
31138764 |
2019 |
|
Adult Glioblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma.
|
31560714 |
2019 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The identification of a regulatory loop whereby miR-302b inhibits NFIA, leading to a decrease in expression of IGFBP-2, may provide novel directions for developing therapies to target glioblastoma tumorigenesis.
|
28323865 |
2017 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nuclear IGFBP2 directly influences the invasive and migratory capacities of human glioblastoma cells, providing a direct link between intracellular (and particularly nuclear) IGFBP2 and cancer hallmarks.
|
25893308 |
2016 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ANOVA tests showed that the difference of mean ΔCt for IGFBP2 gene between healthy subjects and patients with HCMV-positive and HCMV-negative glioblastoma tumors statistically significant.
|
24352760 |
2014 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In view of this, we evaluated the expression of IGFBP isoforms (IGFBP-2, -3, and -5) during malignant progression of astrocytoma and their prognostic significance in glioblastoma.
|
20501753 |
2010 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiling in glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20.
|
18953566 |
2008 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24.
|
17475624 |
2007 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes.
|
12907597 |
2003 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Based on this discovery, subsequent functional studies were initiated that suggest that IGFBP2 overexpression may contribute to the invasive nature of glioblastoma, and that IGFBP2 may exert its function via a newly identified novel binding protein.
|
11770904 |
2002 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGFBP-2(+) macrophage/microglial and glioma cells clustered in the immediate vicinity of focal necrosis of the human gliomas as well as of the rat C6 glioblastoma.
|
11250947 |
2001 |