Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A high Ki-67 proliferation index and positive bcl-2 staining (on cytospin slides or cell block material) of cases not conforming to typical Burkitt lymphoma morphology should prompt FISH analysis for c-MYC and/or IGH-BCL2 rearrangements to identify DHL, particularly if tissue biopsy is not expected.
|
21560252 |
2011 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients demonstrating a terminal deoxynucleotidyl transferase (TdT)-positive precursor B cell phenotype with IGH-MYC rearrangement have been reported to be molecularly distinct from BL and closer to B-ALL/LBL.
|
31705772 |
2020 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
|
20118770 |
2010 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal translocation t(8;14)(q24;q32) with juxtaposition of MYC to enhancer elements in the immunoglobulin heavy chain (IGH) gene locus is the genetic hallmark of the majority of Burkitt lymphoma and a subset of Diffuse large B-cell lymphoma patients.
|
23673335 |
2013 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct.
|
25555480 |
2015 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The DNA sequence of the third-complementarity-determining region (CDRIII) of the immunoglobulin heavy chain (IgH) gene in a case of Burkitt's lymphoma was determined by polymerase chain reaction (PCR) using template DNA extracted from a smear stored at room temperature for more than one year.
|
1908851 |
1991 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal translocation t(8;14) is the hallmark of Burkitt's-lymphoma (BL) and fuses the proto-oncogene c-MYC to the IGH locus.
|
17541401 |
2007 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the capacity of Tat to spontaneously penetrate B-cells could be sufficient to favor the occurrence of MYC-IGH oncogenic rearrangements during erroneous repair, a plausible cause for the increased incidence of Burkitt lymphoma in the HIV-infected population.
|
30701532 |
2019 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cryptic insertion of <i>MYC</i> exons 2 and 3 into the IGH locus detected by whole genome sequencing in a case of MYC-negative Burkitt lymphoma.
|
31073073 |
2019 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have molecularly characterized the recently established Burkitt lymphoma cell line BLUE-1 that carries a t(6;20)(q15;q11.2) rearrangement in addition to the typical t(8;14) with MYC-IGH fusion.
|
21412927 |
2011 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated.
|
21227398 |
2011 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The t(14;18)(q32;q21) involving the IGH and the MALT1 gene has previously been described in PCMZL, whereas the t(14;18)(q32;q21) IGH/BCL2 seems to be restricted to follicular lymphoma and diffuse large B-cell lymphoma.
|
17519619 |
2007 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH.
|
25311808 |
2014 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comparative analysis between RQ-PCR and digital droplet PCR of BCL2/IGH gene rearrangement in the peripheral blood and bone marrow of early stage follicular lymphoma.
|
28419517 |
2017 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR).
|
31385309 |
2020 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of patients with follicular lymphoma (FL) harbor the t(14;18)(q32;q21) IGH/BCL2 gene rearrangement that leads to the overexpression of BCL2 protein, approximately 20% of FL cases lack t(14;18)(q32;q21).
|
31789408 |
2020 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
[BCL-2/IgH translocation in peripheral blood cells of healthy Chinese individuals of Han nationality located in Zhejiang area].
|
16215945 |
2005 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy chain (IgH) gene.
|
17964648 |
2008 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The translocation t(14;18) between the BCL-2 oncogene and the Ig heavy chain (IgH) gene provides the molecular basis for the development of follicular lymphomas.
|
8461469 |
1993 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The FL with signet-ring cell morphology (1/5) tends to lack IGH/BCL2 translocation, and an extended immunohistochemical study is recommended for correct diagnosis and classification of SRCL.
|
28038709 |
2017 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(14;18)(q32;q21) and/or BCL-2-IGH gene rearrangements were the genomic alterations most frequently observed: 50% of S-DLBCL and 30% of dn-DLBCL.
|
16519699 |
2006 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements.
|
18272816 |
2008 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PCR analysis of the HS detected a monoclonal rearrangement of the IGH gene and FISH analysis revealed IGH/BCL2 fusion, a genetic hallmark for FL.
|
20331331 |
2010 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of different primer sets for the detection of IgH gene rearrangement and bcl-2/JH is most desirable for follicular lymphomas.
|
8619747 |
1996 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphomas characteristically carry t(14;18)(q32;q21) which results in IGH-BCL-2 fusion.
|
18656237 |
2008 |