|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we assessed by FISH whether exposure to low concentrations (0.1 μm, 72 hours) of permethrin and malathion induce aberrations in KMT2A and IGH genes, which are involved in the etiology of leukemia and lymphoma.
|
29741206 |
2018 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel t(10;14)(p12;q32)/IGH-BMI1 rearrangement and its IGL variant in six cases of chronic lymphocytic leukemia (CLL) and found that these aberrations were consistently acquired at time of disease progression and high grade transformation of leukemia (Richter syndrome).
|
23873701 |
2013 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated.
|
21227398 |
2011 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IGH rearrangements were backtracked in three RAS-positive patients (which were negative for KRAS mutation at birth) and found to be evident before birth, confirming a prenatal origin for the leukemia clone.
|
20688547 |
2010 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosome 14 copy number-dependent IGH gene rearrangement patterns in high hyperdiploid childhood B-cell precursor ALL: implications for leukemia biology and minimal residual disease analysis.
|
19148138 |
2009 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IGH genes were rearranged in 84% of leukemias with a predominance of incomplete DJ(H) joints.
|
17287854 |
2007 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Distinctive IGH gene segment usage and minimal residual disease detection in infant acute lymphoblastic leukaemias.
|
16197448 |
2005 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate a myeloid to lymphoid lineage switch from an inv(16)(p13q22) positive leukaemia and show that IGH gene rearrangements can occur in the presence of CBFB-MYH11 fusion transcripts.
|
15339697 |
2004 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two of these AML cases and two of three cases of biphenotypic leukaemia exhibited a monoclonal IgH gene rearrangement.
|
10889907 |
2000 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The development of rapid polymerase chain reaction (PCR) protocols for amplification of rearranged heavy chain immunoglobulin (IgH) gene sequences has facilitated the identification of clonal IgH rearrangements in non-Hodgkin's lymphomas (NHL) and leukemias of B lineage.
|
9204991 |
1997 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Leukaemia is a monoclonal disease which frequently displays clonal rearrangement of the T-cell receptor gamma (TCR gamma) and/or immunoglobulin heavy chain (IgH) gene.
|
9507369 |
1997 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PCR analysis of the IgH gene enabled us to obtain a CDR-III leukemia specific product in all cases, thereby providing a specific and diagnostic marker for each B-cell clone.
|
9250798 |
1997 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The development of rapid PCR protocols for amplification of rearranged IgH gene sequences has greatly facilitated the identification of clonal IGH rearrangements in non-Hodgkin's lymphomas (NHL) and leukemias.
|
8609729 |
1995 |