|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clonality detection of heavy chain immunoglobulin (IgH) gene rearrangement has been widely used to establish diagnosis of B-cell NHL.
|
26925633 |
2016 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recurrent non-random balanced chromosomal translocation, usually involving the immunoglobulin heavy chain (IgH) gene or an immunoglobulin light chain gene and a proto-oncogene, which results in the overexpression of the latter under the control of an enhancer or promoter of the former, is a hallmark of many types of non-Hodgkin lymphoma (NHL) of B-cell origin.
|
25197401 |
2014 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgH gene rearrangements as plasma biomarkers in Non- Hodgkin's lymphoma patients.
|
21399237 |
2011 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Based upon the current data of increased rates of lymphoid malignancy, as non-Hodgkin's lymphoma (NHL) is associated with SS, we propose the detection of clonal rearrangements of immunoglobulin heavy chain (IgH) gene in those patients as a predictor of malignant clonal expansion.
|
20408860 |
2010 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of cryptic and variant IGH-MYC rearrangements in high-grade non-Hodgkin's lymphoma by fluorescence in situ hybridization: implications for cytogenetic testing.
|
20303018 |
2010 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiplex PCR for the detection of BCL-1/IGH and BCL-2/IGH gene rearrangements--clinical validation in a prospective study of blood and bone marrow in 258 patients with or suspected of non-Hodgkin's lymphoma.
|
17438702 |
2007 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using a stepwise molecular approach, we were able to demonstrate that the liver infiltrates were Epstein-Barr virus (EBV)-positive, contained monoclonal mature B-cells with immunoglobulin heavy chain gene (IGH) gene rearrangements unrelated to the primary ALL, and thus represented a true secondary non-Hodgkin lymphoma (NHL).
|
14966831 |
2004 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to characterize the clinical and molecular-cytogenetic features of non-Hodgkin's lymphoma (NHL) with double translocation of the immunoglobulin heavy chain (IGH) gene.
|
15370207 |
2004 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In non-Hodgkin lymphoma (NHL), experimental costs are increased, as a large number of primer-probe sets are required because of diversity, due to somatic and ongoing mutations of the IgH gene.
|
12860013 |
2003 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction (PCR) analysis of the CDR3 region of the immunoglobulin heavy chain (IgH) gene which, by demonstrating monoclonality, can provide additional arguments in favour of lymphoid malignancy is now frequently used for the detection and follow up of B cell lymphoma (NHL).
|
11127265 |
2000 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgH gene rearrangement analysis demonstrated monoclonality in 11/12 primary low-grade B-NHLs.
|
10571518 |
1999 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IGH sequences in complex translocations involving band 3q27.
|
9824206 |
1998 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin heavy chain (IgH) gene rearrangement analysis was performed on 27 fine needle aspiration (FNA) specimens (13 reactive hyperplasia, 11 B cell non-Hodgkin's lymphoma (B-NHL), one Hodgkin's disease and two suspicious of non-Hodgkin's lymphoma).
|
9134337 |
1997 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since amplification of the rearranged gene by polymerase chain reaction (PCR) and demonstrating that the amplified sequence is indeed derived from tumor cells is more problematic in non-Hodgkin's lymphoma (NHL) than in other B cell malignancies, we used a comprehensive PCR primer set and formulated stringent selection criteria to identify tumor-specific rearranged IgH genes.
|
9324296 |
1997 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, in another series of 11 patients and a NHL cell line, we demonstrated t(14;18) and t(11;14) in interphase and metaphase cells with a combination of BCL2 (or PRAD1) with IgH gene probes.
|
9209369 |
1997 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunoglobulin heavy chain (IgH) gene rearrangement was analyzed in large tumor cells from four cases of diffuse large cell B-non-Hodgkin's lymphoma and in small reactive T and B lymphocytes from three cases of lymphocytic predominance Hodgkin's disease.
|
9042158 |
1997 |
|
Lymphoma, Non-Hodgkin
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that interphase FISH with IgH gene probes promises to be a rapid and reliable method for use in the diagnosis of B-cell NHL.
|
8547654 |
1996 |