|
Clinical malaria
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for potentially confounding effects of age and pre-season parasitaemia, IgG3 reactivities against each of the major serogroups of MSP2 remained significantly associated with a lower prospective risk of clinical malaria.
|
14507328 |
2003 |
|
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
|
0.010 |
Biomarker
|
disease |
BEFREE |
Also, complement-fixing IgG3 antibodies targeting paranodal proteins have been associated with acute-onset CIDP.
|
31306213 |
2019 |
|
Enterovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Although a mere chance association is possible, the case is interesting as antibody responses involving IgG3 tend to be triggered by protein antigens such as viral envelopes, while humoral immunity is known to be important in the clearance of enteroviral infection.
|
8308322 |
1993 |
|
Hemochromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among all 21 hemochromatosis probands with CVID (n = 4) or IgGSD (n = 17), Ig subclass deficiency patterns were IgG(1) (n = 5), IgG(1) and IgG(3) (n = 6), IgG(3) (n = 9), and IgG(1), IgG(3), and IgG(4) (n = 1).
|
12850493 |
2004 |
|
HEMOCHROMATOSIS, TYPE 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among all 21 hemochromatosis probands with CVID (n = 4) or IgGSD (n = 17), Ig subclass deficiency patterns were IgG(1) (n = 5), IgG(1) and IgG(3) (n = 6), IgG(3) (n = 9), and IgG(1), IgG(3), and IgG(4) (n = 1).
|
12850493 |
2004 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An increase in IgG3 or IgG1 expression in immune cells has been previously demonstrated in immune responses to continuous exposure to the same proteins or peptide antigens and most mucosa-associated lymphoid tissue lymphomas show increased IgG3 and/or IgG1 expression.
|
25674276 |
2014 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
An increase in IgG3 or IgG1 expression in immune cells has been previously demonstrated in immune responses to continuous exposure to the same proteins or peptide antigens and most mucosa-associated lymphoid tissue lymphomas show increased IgG3 and/or IgG1 expression.
|
25674276 |
2014 |
|
Immunologic Deficiency Syndromes
|
0.020 |
Biomarker
|
group |
BEFREE |
Analysis of HIV antibody isotypes showed failure to mount a detectable HIV IgG response over nearly 2 years of infection, in particular IgG(1)- and IgG(3)-specific responses, despite normal responses to common infections and vaccines.
|
20696618 |
2010 |
|
Dengue Fever
|
0.020 |
Biomarker
|
disease |
BEFREE |
Anti-dengue IgG2 and IgG3 subclasses were detected in patients with dengue.
|
28881485 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-CD4 depletion in Ldlr/wild-type mice led to a decrease of serum IgG1 and IgG2c but not IgG3, as well as decreased IgM, associated with increased atherosclerosis and necrotic cores, and a decrease in plaque collagen.
|
28620068 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-CD4 depletion in Ldlr/wild-type mice led to a decrease of serum IgG1 and IgG2c but not IgG3, as well as decreased IgM, associated with increased atherosclerosis and necrotic cores, and a decrease in plaque collagen.
|
28620068 |
2017 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC).
|
16682723 |
2006 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC).
|
16682723 |
2006 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC).
|
16682723 |
2006 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-HER2 IgG3-endostatin also markedly inhibited the growth of human breast cancer SK-BR-3 xenografts in severe combined immunodeficient mice.
|
15956253 |
2005 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-HER2 IgG3-endostatin also markedly inhibited the growth of human breast cancer SK-BR-3 xenografts in severe combined immunodeficient mice.
|
15956253 |
2005 |
|
Immunologic Deficiency Syndromes
|
0.020 |
Biomarker
|
group |
BEFREE |
Anti-HER2 IgG3-endostatin also markedly inhibited the growth of human breast cancer SK-BR-3 xenografts in severe combined immunodeficient mice.
|
15956253 |
2005 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Anti-HER2 IgG3-endostatin inhibited tumor growth significantly more effectively than endostatin, anti-HER2 IgG3 antibody, or the combination of antibody and endostatin.
|
15956253 |
2005 |
|
Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease mediated by IgG1 or IgG3 antibodies to the GluN1 subunit of the NMDAR, resulting in downregulation of NMDARs.
|
28777260 |
2017 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
As IgG3 plays a key role in counteracting the ability of HSV-1 to evade immune responses, these data reinforce the hypothesis of a pathogenetic role of HSV-1 in AD.
|
29578484 |
2018 |
|
Myasthenia Gravis
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a consequence of the distinct IgG4 characteristics, the pathomechanism of MuSK MG is very different from IgG1-and IgG3-mediated autoimmune diseases, such as acetylcholine receptor MG.
|
29377160 |
2018 |
|
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
As a consequence of the distinct IgG4 characteristics, the pathomechanism of MuSK MG is very different from IgG1-and IgG3-mediated autoimmune diseases, such as acetylcholine receptor MG.
|
29377160 |
2018 |
|
Malaria, Falciparum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin.
|
28991911 |
2017 |
|
Chronic urticaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Basophil activation by CU sera is predominantly restricted to IgG1 and IgG3 subclasses.
|
23157716 |
2013 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because high anti-parasite IgG3 and low anti-parasite IgG4 levels were associated with malaria resistance, the chromosomal regions linked to IgG3 and IgG4 levels are of special interest.
|
25521226 |
2016 |