Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
|
16651627 |
2006 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.
|
25352456 |
2015 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
|
16204253 |
2005 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts.
|
28360834 |
2017 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer's disease are also discussed.
|
31535637 |
2020 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
|
27117003 |
2016 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
|
15993441 |
2005 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common familial early onset dementia mutations are found in the genes involved in Alzheimer's disease; the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and 2) genes; the prion protein gene (PRNP) may be involved.
|
15258222 |
2004 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is a rare autosomal dominant disorder caused by an amyloid-beta precursor protein (AbetaPP) 693 mutation that clinically leads to recurrent hemorrhagic strokes and dementia.
|
14678776 |
2003 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effect of early intervention with extract of Huannao Yicong Decoction (还脑益聪方) on the pathologic picture of hippocampus and neurocyte apoptosis in APP transgenic mice model of dementia.
|
21660677 |
2011 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a mutation at a novel site in APP in a three-generation Iowa family with autosomal dominant dementia beginning in the sixth or seventh decade of life.
|
11409420 |
2001 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel APP mutation (E693Δ) that produced a variant Aβ lacking glutamate 22 (E22Δ) in Japanese pedigrees was recently identified to have AD-type dementia without amyloid plaque formation but with extensive intraneuronal Aβ in transfected cells and transgenic mice expressing this deletion.
|
22545812 |
2012 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
|
19818510 |
2009 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice.
|
30504006 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Transmembrane proteins BRI2 and amyloid precursor protein (APP) co-localize with amyloid beta (Abeta) lesions in sporadic Alzheimer disease and mutations in both precursor proteins are linked to early-onset familial cases of cerebral amyloidosis associated with dementia and/or cerebral hemorrhage.
|
16027166 |
2005 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations.
|
21980910 |
2011 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since phosphorylation/dephosphorylation mechanisms are crucial in the regulation of Tau and beta-APP, a superfamily of mitogen-activated protein kinases (MAPKs) has recently emerged as key regulators of the formation of plagues, eventually leading to dementia and AD.
|
15312913 |
2004 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amyloid precursor protein (APP) has been implicated in the pathogenesis of Alzheimer disease, and the accumulation of APP products ultimately leads to the familiar histopathological and clinical manifestations associated with this most common form of dementia.
|
20225047 |
2010 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neuropsychiatric symptoms have been reported as prodromal symptoms of AD-like dementia and soluble forms of beta amyloid peptide (Aβ), the main constituent of insoluble plaques typical of AD brains, have been implicated in such an effect.
|
29879605 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here frame-shift ubiquitin-B and amyloid precursor protein were immunochemically shown to exist in the brain of high pathology control (HPC) patients with AD pathology but without prior dementia.
|
12893422 |
2003 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48).
|
29788013 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AMY plaques are consistently present in familial AD due to presenilin-1 (PS-1), PS-2, and amyloid precursor protein mutations, and they can begin to accumulate before the emergence of dementia.
|
10636133 |
2000 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
|
20157255 |
2010 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
|
21157020 |
2011 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial.
|
16125396 |
2005 |