Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
"How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD."
|
17430250 |
2007 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
2) Family members with codon 717 APP mutations and dementia have low serum vitamin B12 values.
|
30814347 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
APP is an important locus predicting the age at onset of dementia in people with Down syndrome.
|
15184603 |
2004 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amyloid precursor protein (APP) has been implicated in the pathogenesis of Alzheimer disease, and the accumulation of APP products ultimately leads to the familiar histopathological and clinical manifestations associated with this most common form of dementia.
|
20225047 |
2010 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
APP is involved in the pathology of Alzheimer's disease (AD), the most common neurodegenerative disorder causing dementia.
|
29383688 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel APP mutation (E693Δ) that produced a variant Aβ lacking glutamate 22 (E22Δ) in Japanese pedigrees was recently identified to have AD-type dementia without amyloid plaque formation but with extensive intraneuronal Aβ in transfected cells and transgenic mice expressing this deletion.
|
22545812 |
2012 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A phenotype of combined dementia and cerebral microvasculopathy suggested concurrent increases in brain parenchymal and cerebrovascular beta-amyloid peptide (Aβ) deposition in this patient.
|
23931937 |
2014 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.
|
22935789 |
2012 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
|
19286555 |
2009 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A significant component of memory loss in APP transgenic mice is apparently caused by soluble A Beta assemblies, but whether and how much of the dementia within individuals afflicted with AD is caused by these A Beta species is unclear.
|
11773429 |
2002 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease.
|
21209907 |
2010 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
|
16969627 |
2007 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
|
15993441 |
2005 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Also problematic is the alternative hypothesis that, instead of amyloid plaques, it is oligomers of amyloid precursor protein that cause AD.Evidence is presented suggesting amyloid/oligomers as necessary but insufficient causes of the dementia and that, for dementia to develop, requires the addition of cofactors known to be associated with AD.
|
28509380 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the precise mechanism remains to be elucidated, our data suggest a possible role for APP in modifying the PD phenotype as well as a general contribution of genetic factors to the development of dementia in individuals with PD.
|
25604855 |
2015 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease (AD) is the most common cause of dementia that arises on a neuropathological background of amyloid plaques containing beta-amyloid (A beta) derived from amyloid precursor protein (APP) and tau-rich neurofibrillary tangles.
|
12223532 |
2002 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts.
|
28360834 |
2017 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AMY plaques are consistently present in familial AD due to presenilin-1 (PS-1), PS-2, and amyloid precursor protein mutations, and they can begin to accumulate before the emergence of dementia.
|
10636133 |
2000 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation.
|
30703749 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
|
16492752 |
2006 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An elderly man with phenotypic DS and partial trisomy of chromosome 21 (PT21) lacked triplication of APP affording an opportunity to study the role of this gene in the pathogenesis of dementia.
|
27983553 |
2017 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
|
19818510 |
2009 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model.
|
22507317 |
2012 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48).
|
29788013 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
|
16651627 |
2006 |