APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Memory Loss ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 GeneticVariation phenotype BEFREE An increased amount or mutation(s) in PS1, which alters the stoichiometric balance of the gamma-secretase complex, may be the cause of aberrant or increased processing of APP, resulting in Abeta accumulation leading to loss of memory. 19181896 2009
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 GeneticVariation phenotype BEFREE Transgenic mice which carried the mutant form of the beta-amyloid precursor protein gene expressed high concentrations of mutant copy of the gene and exhibited abundant amyloid plaques in the brain and memory loss. 9206974 1997
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 GeneticVariation phenotype BEFREE The amyloid hypothesis does not adequately address the pathogenesis of the disease, however, since transgenic mice that express the pathologic mutations of the APP and presenilin-1 (PS1) genes produce amyloid plaques but fail to exhibit neurodegeneration and memory loss observed in AD patients. 17981591 2008
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE This suggests that the memory loss in APP+PS1 transgenic mice may model the early memory dysfunction in AD before the degeneration of synapses and neurons. 12832546 2003
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice. 24858312 2014
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. 27457810 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats. 27306655 2016
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. 15364477 2004
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation. 28801921 2018
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats. 22484447 2012
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. 18599028 2008
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Three months of treatment of AAV9-GFP-CIP reduced pathologic changes, including τ hyperphosphorylation, (Aβ) deposit, astrocytosis, and microgliosis, which were correlated with the reversal of memory loss and anxiety-like behavior observed in APP/PS1 mice. 28420695 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat. 29729307 2018
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage. 20816828 2010
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss. 22042871 2011
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice, but also significantly contributed to severe memory loss in aged APP/PS1 mice. 31321704 2019
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE More importantly, the Pt<sup>II</sup> -PW<sub>11</sub> greatly reduced Aβ deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity, demonstrating its potential as drugs for AD treatment. 31591753 2019
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Functionally, removing CX3CR1 in human amyloid precursor protein mice worsened the memory retention in passive avoidance and novel object recognition tests, and their memory loss in the novel object recognition test is associated with high levels of interleukin 6. 21771791 2011
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. 23827522 2013
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE The brain formaldehyde level in APP/PS1-transgenic (n=8) mice at age of 3 months and APP-transgenic (n=8) mice at age of 6 months was increased (0.56 ± 0.02 mM), respectively, as compared with their respective age-matched controls, when these two types of AD-like animals, respectively, started to form Aβ deposits and memory loss obviously. 19879019 2011
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. 19664757 2010
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. 31678156 2020
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE A significant component of memory loss in APP transgenic mice is apparently caused by soluble A Beta assemblies, but whether and how much of the dementia within individuals afflicted with AD is caused by these A Beta species is unclear. 11773429 2002
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE The amyloid precursor protein (APP) and its cleavage product Aβ play central roles in synapse and memory loss, and thus are strongly implicated in the pathogenesis of AD. 21199446 2012