APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Memory Loss ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE APP/PS1 double-transgenic mice treated with 3F5 mAb showed reduced memory loss, cognitive decline, and decreased levels of amyloid deposits in the brain. 28662102 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. 27457810 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE A significant component of memory loss in APP transgenic mice is apparently caused by soluble A Beta assemblies, but whether and how much of the dementia within individuals afflicted with AD is caused by these A Beta species is unclear. 11773429 2002
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. 18191838 2008
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 GeneticVariation phenotype BEFREE An increased amount or mutation(s) in PS1, which alters the stoichiometric balance of the gamma-secretase complex, may be the cause of aberrant or increased processing of APP, resulting in Abeta accumulation leading to loss of memory. 19181896 2009
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage. 20816828 2010
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation. 28801921 2018
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. 15364477 2004
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway. 26420483 2015
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease. 19770021 2009
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Functionally, removing CX3CR1 in human amyloid precursor protein mice worsened the memory retention in passive avoidance and novel object recognition tests, and their memory loss in the novel object recognition test is associated with high levels of interleukin 6. 21771791 2011
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE Here, we use the J20-APP AD mouse model that displays spatial memory loss as well as reduced slow gamma amplitude and phase-amplitude coupling to theta oscillations phase. 31757962 2019
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. 23827522 2013
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. 19664757 2010
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age. 26480858 2016
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE More importantly, the Pt<sup>II</sup> -PW<sub>11</sub> greatly reduced Aβ deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity, demonstrating its potential as drugs for AD treatment. 31591753 2019
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation. 25213453 2014
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946 2017
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice. 24858312 2014
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 AlteredExpression phenotype BEFREE Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention. 27388605 2016
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats. 22484447 2012
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. 18599028 2008
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype CTD_human Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice. 25881725 2015
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 AlteredExpression phenotype BEFREE Somatostatin (SST) blocks the aggregation of Aβ and inflammation whereas reduction of SST levels in the CSF and brain tissue is associated with impaired cognitive function and memory loss. 29700775 2019
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.400 Biomarker phenotype BEFREE TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. 31678156 2020