|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, CCK-8 assays were used to measure the tumor-suppressing effect of miR-373-3p on A549 and it was demonstrated that overexpression of miR-373-3p may more effectively inhibit the proliferation of A549 compared with APP si-RNA.
|
29387243 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The overexpression of amyloid precursor protein was significantly associated with tumor stage, tumor size, histological grade and lymph node metastasis.
|
30021247 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The functional roles of APP in breast cancer were studied in vitro and tumor xenograft model using siRNA.
|
30470613 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, we detected the expression of amyloid precursor protein and histone deacetylase 1 in hepatocellular carcinoma and adjacent tissues, as well as the correlations among histone deacetylase 1, amyloid precursor protein, and tumor stage.
|
27507654 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pan-cytokeratin and APP were up-regulated in tumor versus non-tumor tissue, and were selected in the predictive cluster to discriminate colon cancer type.
|
29128960 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Histamine receptor1 (HRH1), neuropilin2 (NRP2), ephrin-B1 (EFNB1), neural growth factor receptor (NGFR) and amyloid precursor protein (APP) were differentially overexpressed in basal and HER2-enriched tumor samples and syntaxin 1A (STX1A) was overexpressed in HER2-enriched and luminal B tumors.
|
26673618 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion.
|
26840089 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We confirm selective inhibition of PAFAH1b2/3 in cancer cells by P11 using an ABPP protocol adapted for in situ analysis of reversible inhibitors and show that this compound impairs tumor cell survival, supporting a role for PAFAH1b2/3 in cancer.
|
25602368 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Regression analysis indicated that AS transcript of NUMB PRR(L) correlated with tumor size (P<0.01), while AS transcripts of APP and VEGFA correlated with results of laboratory examinations.
|
26261495 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GRP78 is involved in APP maturation and inhibition of tumor cell growth by down-regulation of APP and secreted soluble APPalpha.
|
20145244 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gain-of-function and loss-of-function studies revealed that APP promotes the tumor growth of prostate cancer.
|
19117996 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This suggests that the APP family of proteins is transported to the cell membrane by synaptic microvesicles and that they may influence tumour cell adhesion and invasiveness.
|
18430897 |
2008 |