APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Age-related cognitive decline ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0236848
Disease: Age-related cognitive decline
Age-related cognitive decline 		0.040 GeneticVariation disease BEFREE This effect closely mimics the phenotype of APP A673T, a recently discovered mutation that protects carriers against AD and age-related cognitive decline. 28115709 2017
CUI: C0236848
Disease: Age-related cognitive decline
Age-related cognitive decline 		0.040 GeneticVariation disease BEFREE A673T, a rare variant in the amyloid-β precursor protein gene, shows a protective potential against Alzheimer's disease (AD) and age-related cognitive decline in an Icelandic population. 24126161 2014
CUI: C0236848
Disease: Age-related cognitive decline
Age-related cognitive decline 		0.040 GeneticVariation disease BEFREE A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. 22801501 2012
CUI: C0236848
Disease: Age-related cognitive decline
Age-related cognitive decline 		0.040 Biomarker disease BEFREE TASTPM mice over-express human APP and beta amyloid protein and show age related cognitive decline and neuroinflammation. 17324270 2007