APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Iron Overload ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.030 AlteredExpression disease BEFREE Dietary iron overload induces iron disorder and Aβ and phospho-τ expression in the hippocampus of adult WT and APP/PS1 transgenic mice. 31373375 2019
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.030 Biomarker disease BEFREE Our data provide the first evidence that iron overload alters the neuronal sAPPα distribution and directly inhibits β-secretase activity. 28836584 2018
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.030 Biomarker disease BEFREE Thus APP-dependent iron export may alleviate oxidative stress by minimizing labile iron thus protecting neurons from iron overload during stroke and hemorrhage. 24513321 2014