APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Dementia in Parkinson's disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0349081
Disease: Dementia in Parkinson's disease
Dementia in Parkinson's disease 		0.010 Biomarker disease BEFREE Multiple regression analysis revealed that PD patients carrying rare variants in the <i>APP, PSEN1, PSEN2</i>, and <i>GRN</i> genes exhibit lower cognitive tests scores than non-carrier PD patients (<i>p</i> = 2.0 × 10<sup>-4</sup>), independent of age at PD diagnosis, age at evaluation, <i>APOE</i> status or recruitment site. 29692703 2018