APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Short-term memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2363813
Disease: Short-term memory impairment
Short-term memory impairment 		0.010 GeneticVariation disease BEFREE Crossing amyloid precursor protein transgenic mice with heterozygous mutant mice resulted in elevated Aβ43, impairment of short-term memory and acceleration of amyloid-β pathology, which accompanied pronounced accumulation of Aβ43 in plaque cores similar in biochemical composition to those observed in the brains of affected individuals. 21725313 2011