|
Hepatitis D Infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hepatitis delta virus (HDV)-RNA shows a microheterogeneity at nucleotide 1015 resulting in the production of two co-terminal forms of the HDV-associated antigen (HDAg), referred to as p24 and p27.
|
1822506 |
1991 |
|
Lupus Vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
This competitor from a lupus spleen chromatographed on phosphocellulose and showed size fractionation during gel filtration similar to known p27 to p30 viral proteins.
|
4372412 |
1974 |
|
Lupus Erythematosus, Discoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
This competitor from a lupus spleen chromatographed on phosphocellulose and showed size fractionation during gel filtration similar to known p27 to p30 viral proteins.
|
4372412 |
1974 |
|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
This competitor from a lupus spleen chromatographed on phosphocellulose and showed size fractionation during gel filtration similar to known p27 to p30 viral proteins.
|
4372412 |
1974 |
|
Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
This competitor from a lupus spleen chromatographed on phosphocellulose and showed size fractionation during gel filtration similar to known p27 to p30 viral proteins.
|
4372412 |
1974 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To determine the role of p27 in tumorigenesis, we examined its mutational status in 74 non-Hodgkin's lymphomas (NHLs) (52 of B-cell phenotype, 22 of T-cell phenotype), 5 lymphoma cell lines, and 42 adult T-cell leukemias/lymphomas (ATLs) using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and Southern blot analyses.
|
7655021 |
1995 |
|
Lymphoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
A nonsense mutation (stop codon) that could result in expression of a truncated nonfunctional p27 protein was detected at codon 76 in one case of acute lymphomatous ATL, but not in matched normal tissues.
|
7655021 |
1995 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
To determine the role of p27 in tumorigenesis, we examined its mutational status in 74 non-Hodgkin's lymphomas (NHLs) (52 of B-cell phenotype, 22 of T-cell phenotype), 5 lymphoma cell lines, and 42 adult T-cell leukemias/lymphomas (ATLs) using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and Southern blot analyses.
|
7655021 |
1995 |
|
Hematologic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results indicate that p27 gene alterations are rare events in NHLs and ATLs, but may play an important role in the pathogenesis of some hematologic malignancies.
|
7655021 |
1995 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The involvement of p27 in the negative regulation of cell proliferation suggests that it may also function as a tumor suppressor gene.
|
7882310 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In situ hybridization to some of the p27-overexpressing tumors showed that the p27 RNA is localized in cancer cells and sometimes also in fibroblastic cells of tumor stroma. p27 RNA levels in the tumors did not correlate with the presence of estrogen receptor or with the expression of the estrogen-induced pS2 gene.
|
8358738 |
1993 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further studies are now necessary to elucidate the cause of p27 gene overexpression in breast carcinoma and in particular to determine whether it corresponds to chromosomal rearrangements in the 14q32 region and/or to induction by interferons of the alpha/beta type.
|
8358738 |
1993 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to elucidate the possible role of p27 mutations in the development or progression of human breast cancer, we have studied the occurrence of genetic abnormalities in this gene in a series of 30 primary breast carcinomas.
|
8557269 |
1996 |
|
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the basis of these results, we suggest that alterations in the integrity of the human p27 gene are not common events in human breast carcinomas.
|
8557269 |
1996 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that p27 mutations are a rare event in breast cancer, but may play an important role in the development of a minority of these cancers.
|
8625318 |
1996 |
|
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To determine whether p27 alterations may be involved in tumorigenesis, we examined its mutational status in 36 primary breast carcinomas and 9 breast cancer cell lines using PCR-single-strand conformational polymorphism, direct DNA sequencing, and Southern blot analysis.
|
8625318 |
1996 |
|
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that p27 mutations are a rare event in breast cancer, but may play an important role in the development of a minority of these cancers.
|
8625318 |
1996 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To elucidate the importance of CDKI genes, including the p18 as well as the p16 and p27 genes in tumorigenesis of neuroblastoma, 25 neuroblastomas were analyzed for deletions by Southern blot analysis and for point mutations by polymerase chain reaction-single strand conformational polymorphism.
|
8630967 |
1996 |
|
Neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Abnormalities, including deletions and point mutations of the p16, p18, and p27 genes, were not observed in this series of neuroblastomas.
|
8630967 |
1996 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
All of them recognised the p27 kDa protein which they were raised against and 2D2 and 3D7 recognised the core component of an HCV Recombinant Immunoblot Assay (RIBA).
|
8923286 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, changes in p27 and cyclin E protein levels in tumors might be more common than previously anticipated and may be indicators of tumor behavior.
|
9018243 |
1997 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that carcinomas with low or absent p27 protein displayed enhanced proteolytic activity specific for p27, suggesting that low p27 expression can result from increased proteasome-mediated degradation rather than altered gene expression.
|
9018245 |
1997 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The absence of p27 protein expression is thus a powerful negative prognostic marker in colorectal carcinomas, particularly in stage II tumors, and thereby may help in the selection of patients who will benefit from adjuvant therapy.
|
9018245 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cell-cycle inhibitor p27 is a potential tumor suppressor, but its gene has never been found inactivated in human tumors.
|
9018245 |
1997 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, confirmation of the involvement of the proteasome-mediated proteolysis in p27 degradation should stimulate new strategies of nonsurgical treatments of non-small cell lung cancer.
|
9270000 |
1997 |