|
Hyperactive behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we show hyperactivity of cyclin A-CDK induces G2/M-phase arrest in human cell lines with relatively low expression of p21 and p27.
|
31760882 |
2020 |
|
Gynecomastia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Statistically significant positive correlations between GT and ASPS data were as follows: breast lift: "mastopexy" (R = 0.445, P = 0.025); male breast reduction: "gynecomastia surgery" (R = 0.45, P = 0.024); and breast reconstruction: "tissue expander" (R = 0.806, P ≤ 0.001) and "TRAM flap reconstruction" (R = 0.764, P = 0.002).
|
30870175 |
2019 |
|
Leishmaniasis, Visceral
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leishmania major p27 gene knockout as a novel live attenuated vaccine candidate: Protective immunity and efficacy evaluation against cutaneous and visceral leishmaniasis in BALB/c mice.
|
31047672 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ERβ induced stable PML expression causes a decline of its target protein Survivin and simultaneously provides a stable docking platform leading to stabilisation of its target Foxo3a, further causing transcriptional upregulation of pro-apoptotic factors p21 and p27.
|
31506431 |
2019 |
|
Toxoplasmosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection.
|
30770800 |
2019 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spontaneously hypertensive rats underwent 15 min middle-cerebral artery occlusion and were randomized into control or treatment group, which received TRAM-34 intraperitoneally for 4 weeks starting 12 h after reperfusion.
|
31652564 |
2019 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRAM -34 significantly attenuated cardiac fibrosis and the inflammatory reaction and reduced the number of fibroblast precursor cells and myofibroblasts.
|
30563389 |
2019 |
|
Epithelial hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results also provide a mechanistic explanation for the functional link between hyperinsulinemia and p27 loss in the pathogenesis of endometrial epithelial hyperplasia in PCOS patients.
|
29112933 |
2018 |
|
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results also provide a mechanistic explanation for the functional link between hyperinsulinemia and p27 loss in the pathogenesis of endometrial epithelial hyperplasia in PCOS patients.
|
29112933 |
2018 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Caffeine also reduces infarct size after myocardial infarction in prediabetic mice and increases mitochondrial p27.
|
29927970 |
2018 |
|
Prolactinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A similar trend was also observed for p21 and p27 protein levels in PRL specimens through western-blot (P < 0.01, respectively).
|
29230669 |
2018 |
|
Hyperparathyroidism, Primary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We aimed to investigate the expressions of p27 kinase inhibitory protein 1 (p27<sup>Kip1</sup>) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT).
|
29589297 |
2018 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Caffeine also reduces infarct size after myocardial infarction in prediabetic mice and increases mitochondrial p27.
|
29927970 |
2018 |
|
Fourth cranial nerve paresis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of MyoD, insulin like growth factor binding protein, thioredoxin and p27 in secondarily overacting inferior oblique muscles with superior oblique palsy.
|
29843669 |
2018 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression profile and cellular localizations of mucin proteins, CK7, and cytoplasmic p27 in Barrett's esophagus and esophageal adenocarcinoma.
|
29803118 |
2018 |
|
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, selective participation of c-Rel with p50 that in cross-talk with AP-1/Fra-2 induced poor differentiation and aggressive tumorigenesis mainly in HPV<sup>-ve</sup> smokers while HPV infection induced expression of p65 and p27 leading to well differentiation and better prognosis preferably in non-smoking TSCC patients.
|
30250646 |
2018 |
|
Squamous cell carcinoma of tongue
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, selective participation of c-Rel with p50 that in cross-talk with AP-1/Fra-2 induced poor differentiation and aggressive tumorigenesis mainly in HPV<sup>-ve</sup> smokers while HPV infection induced expression of p65 and p27 leading to well differentiation and better prognosis preferably in non-smoking TSCC patients.
|
30250646 |
2018 |
|
Corneal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we tested the hypothesis that blockade of KCa3.1 by a selective KCa3.1 inhibitor, TRAM-34, could augment a novel interventional approach for controlling corneal fibrosis in our established in vitro model of corneal fibrosis.
|
29554088 |
2018 |
|
Metastatic Prostate Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Induced overexpression of AR led to an increase in the expression of EGFR, p-GSK-3β and decrease in p27 expression in PCa cell lines in the presence of androgen stimulation.
|
30134822 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Induced overexpression of AR led to an increase in the expression of EGFR, p-GSK-3β and decrease in p27 expression in PCa cell lines in the presence of androgen stimulation.
|
30134822 |
2018 |
|
Well Differentiated Pancreatic Endocrine Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HuD expression was frequently lost in many human pancreatic NETs, and these pancreatic NETs showed aggressive clinicopathological phenotypes with low p27 levels, increased tumor size, higher World Health Organization grade and pT stage of the tumor, and the presence of angioinvasion.
|
30014466 |
2018 |
|
Chronic Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, upregulation of the expression levels of Saa3, Ticam2, Reg3b, Ocxt2a, and Xcr1 may be associated with the pathogenesis of CKD.
|
29388058 |
2018 |
|
Carcinoma of urinary bladder, invasive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings improve our understanding of p27 and PHLPP2 roles and their crosstalk in regulation of BC invasion, which further contributes to improve the current strategy for invasive bladder cancer therapy.
|
29930380 |
2018 |
|
Luminal A Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of our study was to determine the association between expression of c-Myc and the loss of p27 by immunohistochemistry (IHC) in the four major subtypes of breast cancer (BC) (Luminal A, Luminal B, HER2, and Triple Negative) and with other clinicopathological factors in a population of 202 African-American (AA) women.
|
29715580 |
2018 |
|
Luminal B Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of our study was to determine the association between expression of c-Myc and the loss of p27 by immunohistochemistry (IHC) in the four major subtypes of breast cancer (BC) (Luminal A, Luminal B, HER2, and Triple Negative) and with other clinicopathological factors in a population of 202 African-American (AA) women.
|
29715580 |
2018 |