FAS, Fas cell surface death receptor, 355

N. diseases: 754; N. variants: 47
Disease: Leukemia, T-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 Biomarker disease BEFREE Recently, CD4 T stem cell memory (T<sub>SCM</sub>) Fas<sup>hi</sup> cells have been identified as the hierarchical cellular apex of ATL, but a possible link between FAS, apoptosis, proliferation and IFN response in ATL has not been studied. 29721391 2018
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 Biomarker disease BEFREE To investigate this phenomenon, we explored FAS transcript levels, cell-surface FAS protein expression and susceptibility to FAS-mediated apoptosis in four CTCL lines (MyLa, HH, SZ4, and SeAx), freshly isolated leukemic cells from a patient with SS, an acute lymphoblastic leukemia T-cell line (Jurkat), and JFL (a FAS-low variant of Jurkat). 18923451 2009
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 GeneticVariation disease BEFREE In conclusion, our results demonstrate that a functional Fas promoter polymorphism is significantly associated to susceptibility, clinical manifestation, and survival in ATL. 17962369 2008
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 GeneticVariation disease BEFREE Adult T-cell leukemia (ATL), which is abundant with Fas (Apo-1/CD95), has the characteristic feature of high tumor burden, suggesting that ATL cells probably prolong their lives as a result of escape from apoptosis. 12613509 2002
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 GeneticVariation disease LHGDN The conformational alteration of the mutated extracellular domain of Fas in an adult T cell leukemia cell line. 12207908 2002
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 GeneticVariation disease BEFREE Several groups have searched for mutations in the FAS receptor, a well-characterized apoptotic protein carrying a death domain, and reported the existence of rare mutations in multiple myeloma, T-acute lymphoblastic leukemia (T-ALL), and adult T-cell leukemia. 11166462 2001
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 Biomarker disease BEFREE Soluble Fas (APO-1/CD95) isoform in adult T-cell leukemia. 11342370 2001
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 GeneticVariation disease BEFREE Mutation of the Fas gene may be one of the mechanisms underlying the progression of ATL. 10190897 1999
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.090 GeneticVariation disease BEFREE These findings indicate that mutation of the Fas gene may be associated with the progression of ATL and with resistance to anticancer drugs. 9573032 1998