|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 alpha and/or IL-1 beta were identified in the GCF of 15 of 15 patients having untreated periodontitis.
|
2141875 |
1990 |
|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-1 (IL-1)-producing cells in inflamed gingival tissues obtained from patients with periodontitis were examined by combined immunohistochemistry and in situ hybridization.
|
2053589 |
1991 |
|
Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ability of IL-1 to stimulate this expression may define a pivotal role for this cytokine in the pathogenesis of periodontitis.
|
8809309 |
1996 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functionally, the specific periodontitis-associated IL-1 genotype comprises a variant in the IL-1B gene that is associated with high levels of IL-1 production.
|
9049801 |
1997 |
|
Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One polymorphism of the composite periodontitis-associated genotype (PAG) has been functionally linked with expression of high levels of IL-1.
|
10397510 |
1999 |
|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Another IL-1 genetic pattern, characterized by the IL-1B (-511) and IL-1RN (+2018) markers, is associated with atherosclerotic plaque formation, as measured by angiography and arterial wall thickness, but not periodontitis.
|
10685360 |
1999 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to compare microbiological parameters in IL-1 genotype negative and positive adult subjects with a range of periodontitis severities.
|
11073323 |
2000 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the primary aim of this study was to determine the prevalence of the IL-1 composite genotype in individuals of Chinese heritage, since epidemiologic studies indicate that periodontitis is widespread among ethnic Chinese.
|
10711606 |
2000 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The lack of any association between the IL1 polymorphisms and GEOP, in the population presented here, brings into doubt the usefulness of these candidate genes as markers of susceptibility to this form of periodontitis.
|
11350506 |
2001 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the relationship between IL-1 genotype and periodontitis in a prospective longitudinal study in an adult population of essentially European heritage.
|
11737511 |
2001 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 52 teeth (3.3%) out of 1,566 were lost due to periodontitis between T0 and T2; 28 of 957 (2.9%) in the IL-1 genotype negative group and 24 of 609 (3.9%) in IL-1 genotype positive group.
|
11453239 |
2001 |
|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review summarizes some current information on the importance of IL-1 in periodontitis as well as the signal transduction of IL-1, from binding to its cell-surface receptors, to the activation of cytoplasmic mediators and transcription factors responsible for the induction of target genes.
|
11332522 |
2001 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-1A(-889) and a composite genotype [IL-1A(-889)2 plus IL-1B(+3953)2] showed no association with the incidence of periodontitis, disease onset or disease severity.
|
11858158 |
2002 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects were evaluated to confirm that the plaque index and gingival index were < or = 1.0, and to categorize past periodontitis (moderate or severe) and IL-1 genotype (1A +4845 plus IL-1B +3954).
|
14584862 |
2003 |
|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genetic association of interleukin-1 (IL-1) with periodontitis has been investigated in different populations.
|
12974682 |
2003 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects bearing at least one copy of the variant allele 2 at positions IL-1A -889 and IL-1B +3954 (genotype positive) had an enhanced smoking-associated periodontitis risk as compared to their IL-1 genotype-negative counterparts.
|
15068111 |
2004 |
|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show statistically significant (p <or= 0.05) differences between genotype frequencies in aggressive and controls (IL-1B +3954 & IL-6 -174); chronic and controls (IL-6 -174 & VDR -1056); chronic and aggressive periodontitis (IL-1A -889); and periodontitis as a whole and controls (VDR -1056, TLR-4 399 & IL-6 -174).
|
16304445 |
2005 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The aims of this study were to determine the prevalence of the IL-1A-889 and IL-1B+3954 (previously described as +3953) polymorphisms in Chileans and their association with periodontitis.
|
15974847 |
2005 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aims of this study were to determine the prevalence of the IL-1A-889 and IL-1B+3954 (previously described as +3953) polymorphisms in Chileans and their association with periodontitis.
|
15974847 |
2005 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association between the IL1 B (+3954) gene polymorphism and the occurrence of different clinical forms of periodontitis in a sample of Brazilian individuals.
|
15966908 |
2005 |
|
Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HIV-positive and HIV-negative subjects with periodontitis were genotyped for IL-1 by polymerase chain reaction and restriction enzyme digestion.
|
16931944 |
2006 |
|
Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This may suggest that among subjects undergoing SPT, a lower bacterial load is required in IL-1 gene-positive subjects to develop the same level of periodontitis as in IL-1 gene-negative subjects.
|
16881809 |
2006 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-1 genetic variations are associated with variation in both the inflammatory response and the clinical presentation of a range of diseases, including coronary artery disease, Alzheimer disease, gastric cancer, and periodontitis.
|
16470016 |
2006 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While findings from some publications rejected a possible role of IL-1 composite genotype on progression of periodontitis after various therapies, other reported a prognostic value for disease progression of the positive IL-1 genotype status.
|
17378887 |
2007 |
|
Periodontitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
While findings from some publications rejected a possible role of IL-1 composite genotype on progression of periodontitis after various therapies, other reported a prognostic value for disease progression of the positive IL-1 genotype status.
|
17378887 |
2007 |