|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is particularly important given recent completed and ongoing clinical trials with IL-1 biologics that have had varying degrees of failure and success as therapeutics for disease modification in asthma and COPD.
|
31727692 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that IL-1α and IL-1β are elevated in both bronchoalveolar lavage fluid and sputum from human asthmatics sensitized to fungi, implicating an association with IL-1α, IL-1β, or IL-1RA in fungal asthma severity.
|
31550242 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 receptor-like 1 (IL1RL1) and thymic stromal lymphopoietin (TSLP) play important roles in asthma in various ways.
|
31066119 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate the release of the alarmin IL-1α after ozone exposure and that the acute respiratory barrier injury and inflammation and airway hyperreactivity are IL-1α-dependent.
|
29867931 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 receptor appears to be a marker of neutrophilic inflammation and airflow obstruction in patients with asthma, who have a wide range of disease severity.
|
29103994 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
|
28528200 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gain-of-function IL1A rs17561 resulted significantly associated with a reduced pulmonary capacity in asthmatic children.
|
29154202 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate if IL-1α and β polymorphism is associated with asthma in a pediatric population and if the genotype affects its serum level.
|
29034996 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-37 a New IL-1 Family Member Emerges as a Key Suppressor of Asthma Mediated by Mast Cells.
|
27982737 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our study identifies caspase-8 as a master regulator of IL-1 cytokines that contribute to the pathogenesis of asthma and implicates caspase-8 inhibition as a potential therapeutic strategy for asthmatic patients.
|
27007676 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive pulmonary disease (COPD).
|
28262817 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with co-morbid GAD and asthma showed higher sputum IL-1 AUC, sputum IL-6 AUC and sAA AUC.
|
28716529 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, there was a significant relationship between the A/A genotype in the -152 G/A IL1-7A SNP and the coexistence of AD and asthma (P < 0.04).
|
25223230 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Microbial adhesion (virulence) and Proteobacteria abundance were significantly associated with variation in the expression of the upstream regulator IL1A; suggesting that microbiome characteristics modulate host inflammatory and immune systems during asthma.
|
26125632 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most recent work in systems biology and asthma has occurred in the area of genomics (e.g., pharmacogenomics and gene-environment interactions), protein interaction networks [e.g., interleukin (IL)-33/IL-1 receptor-like 1 signaling], cluster analysis of asthma patients (e.g., application of severe asthma research program clusters to a general urban asthma population), and multiscale approaches to asthma encompassing data from the molecule to whole organ (e.g., modeling of airways hyperresponsiveness).
|
24275925 |
2014 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma.
|
25278425 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).
|
24568840 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
High risk association of IL-1 receptor antagonist (IL-1RN) VNTR polymorphism with asthma in a North Indian population: a pilot study.
|
23602199 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation, notably the type-2 response implicated in asthma.
|
23855553 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Global gene expression profiling of APM treated HBE activated genes related to xenobiotic metabolism (CYP 1B1), endogenous ROS generation and response genes (DUOX1, SOD2, PTGS2) and pro-inflammatory responses associated with asthma or COPD such as IL-1α, IL-1β, IL-8, and CCL20.
|
21703343 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The discovery that the IL-1RI-IL-1 and ST2-IL-33 pathways are crucial for allergic inflammation has raised interest in these receptors as potential targets for developing new therapeutic strategies for bronchial asthma.
|
20671916 |
2010 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-33 is a recently characterized IL-1 family cytokine and found to be expressed in inflammatory diseases, including severe asthma and inflammatory bowl disease.
|
20689814 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence on the implications of this cytokine in asthma is lacking.
|
19801525 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to investigate the relationship between polymorphisms of IL-1beta promoter region -511C/T and IL-1 receptor antagonist (IL-1Ra) gene (IL-RN) and bronchial asthma in Turkish children.
|
18926055 |
2009 |