|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interleukin 1 alpha (<i>IL1A</i>) polymorphisms and risk of endometriosis in Iranian population: a case-control study.
|
31248297 |
2020 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results reveal that IL-1/IL-1R1, IL-33/IL-33R and associated downstream signaling molecules are involved in the pathogenesis of endometriosis, and may provide novel therapeutic targets for endometriosis.
|
31507610 |
2019 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The impairment of the IL-1 family cytokine-network may lead to changes in the activation of immune system in the peritoneal cavity of women with endometriosis.
|
29332562 |
2018 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A known dysmenorrhea signal near NGF replicated in our data (rs12030576; P = 1.1 × 10<sup>-19</sup>) and was associated with RP4-663N10.1 expression, a putative lncRNA enhancer of NGF, while a novel dysmenorrhea signal in the IL1 locus (rs80111889; P = 1.9 × 10<sup>-16</sup>) contained SNPs previously associated with endometriosis, and GWAS SNPs were most significantly associated with IL1A expression.
|
29855537 |
2018 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic Variation at Chromosome 2q13 and Its Potential Influence on Endometriosis Susceptibility Through Effects on the IL-1 Family.
|
29669463 |
2018 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to further investigate the eight IL1A SNPs for association with endometriosis using an independent sample of 3908 endometriosis cases and 8568 controls of European and Japanese ancestry.
|
25336714 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of rs6542095 at the IL1A locus with 'All' (p = .066) and 'Grade_B' (p = .01) endometriosis is noteworthy because this is the first successful replication in an independent population.
|
26337243 |
2015 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lower circulating levels of sIL1RAP points to a significant impairment in the counter-regulatory mechanisms of IL1, which in view of the cytokine's potent inflammatory and growth-promoting properties may play a significant role in the pathophysiology of endometriosis.
|
24935223 |
2014 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The four common variants (rs17561, rs1304037, rs2856836 and rs3783553) in IL1A were significantly associated with endometriosis (P=0.0024, 0.0024, 0.0014 and 0.0061, respectively).
|
23635948 |
2013 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, the IL-1α -889C>T, IL-1 receptor antagonist (IL-1RA) 86-bp microsatellite, IL-1 receptor 1 (IL-1R1) 52C>A, 294C>T, 1498T>C, 1632A>G, IL-1R2 rs2072472 C>T and rs7561460 C>T polymorphisms were analyzed in women with (n = 138) and without (n = 214) endometriosis using restriction fragment length polymorphism (RFLP) analysis, TaqMan assay, or DNA sequencing.
|
22509941 |
2012 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results pointed to impairment of the secretion of the IL-1 cytokine family in endometriosis.
|
22537218 |
2012 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This points to a deficiency in the local control of IL-1 that, in view of the cytokine's elevated levels and potent proinflammatory, angiogenic, and growth-promoting effects, may contribute to endometriosis development.
|
22841820 |
2012 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of the wide spectrum of IL-1 inflammatory and growth-promoting effects, downregulation of sIL1RAcP, which is known for inhibiting IL1, indicates a profound defect in the capability of endometrial cells of women with endometriosis to counterregulate IL-1 effects and may represent an important mechanism underlying the ability of these cells to implant and develop into host tissues.
|
21272866 |
2011 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 1 (IL1) may play an important role in endometriosis-associated pelvic inflammation, and natural specific inhibitors, including soluble IL1 receptor accessory protein (sIL1RAcP) and soluble IL1 receptor type 2 (sIL1R2), are critical for counterbalancing the pleiotropic effects of IL1.
|
21958553 |
2011 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of note, four of the top five SNPs with P-values <10(-5) were located in and around IL1A (interleukin 1α), which might be a functional candidate gene for endometriosis.
|
20844546 |
2010 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
This study revealed an imbalance between IL1beta and its decoy inhibitory receptor type 2 in women with endometriosis, which was particularly obvious in those who were infertile, and suggests that a defect in the local control of IL1 may be involved in the pathophysiology of endometriosis and related infertility.
|
17919610 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The decrease in IL1R2 mRNA levels in eutopic endometrial tissue of endometriosis women, and the concomitant increase in IL1R1 mRNA levels in ectopic implants, reveal a profound defect in IL1R 1 and IL1R2 gene expression which may accentuate the capability of this tissue to respond to IL1 and favor its ectopic growth.
|
17517439 |
2008 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Such an interaction between IL-1 and MIF may have an important impact on endometriotic cell growth and endometriosis pathophysiology.
|
17997749 |
2007 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present findings suggest that the dysregulation of IL-1/IL-1-R system relates to immunological dysfunction in endometriosis.
|
15472211 |
2004 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess the ability of peripheral blood serum from women with endometriosis to induce monocyte chemotactic protein-1 (MCP-1) secretion by monocytes and the putative role of the interleukin-1 (IL-1) system in endometriosis-associated monocyte activation.
|
12372465 |
2002 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The reduced levels of IL-1RII mRNA in the endometrium of women suffering from endometriosis reveals a profound defect in IL-1RII gene expression and, consequently, a reduced capability of endometrial tissue to down-regulate IL-1 activity.
|
11804955 |
2002 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of endometriosis with IL-1 beta-511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist gene polymorphisms doesn't exist.
|
11665666 |
2001 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1 alpha mRNA was expressed by seven of 10 patients with endometriosis but by only one of the control group; this was again significantly different (P < 0.04).
|
9239723 |
1997 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that peritoneal macrophages express IL-1ra mRNA rather than IL-1 beta mRNA with the progress of endometriosis and that peritoneal macrophages may secrete IL-1ra protein that modulates the effects of IL-1.
|
1371258 |
1992 |