|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we examined the association between IL-1ß rs1143634 and rs16944 polymorphisms and PD in non-smoking and smoking patients.
|
30445239 |
2019 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Since then, many studies have suggested that IL-1, particularly IL-1β plays key roles in the pathogenesis of periodontal diseases.
|
29360244 |
2018 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Further studies are needed to confirm these results and to understand the mechanisms behind the observed association between IL-1 SNPs and periodontal disease.
|
29577711 |
2018 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that the NLRP3 inflammasome, followed by a response from the IL-1 family, is critical in periodontal disease induced by wild-type P. gingivalis challenge via sustained inflammation.
|
27665233 |
2017 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
PKR prevented tumor necrosis factor-α- and interleukin 1α-induced bone resorption in calvaria and artificially induced periodontal disease in rat.
|
27987116 |
2017 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Current evidence suggests that many GWAS and IL1 SNPs are associated with periodontal diseases but their functional role remains ambiguous.
|
27569042 |
2016 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results of this study showed that the heterozygous variant genotype of the IL1 rs16944 was significantly associated with a reduced risk of periodontal disease in young Japanese women.
|
24460370 |
2014 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to determine the prevalence of IL-1β+3954 and IL-1α-889 polymorphism in a group of Lebanese individuals of homogeneous ethnicity and the possible association between genotype positive individuals and the severity of periodontal disease.
|
23241110 |
2013 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
IL-1-polymorphism and severity of periodontal disease.
|
21449691 |
2012 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Since the first report, ≥125 studies have examined IL-1 gene variation in relation to periodontal disease.
|
22348697 |
2012 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms found in the IL-1 family genes have been associated with susceptibility of periodontal disease.
|
21414132 |
2012 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study examined the association of IL1 genetic polymorphisms (IL-1A +4845, IL-1B +3954 & IL-1RN +2018) with periodontal disease status of Down syndrome (DS) individuals.
|
21712624 |
2011 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-1 (IL-1) is a proinflammatory cytokine that is highly elevated in response to bacterial biofilms and is a potential risk factor for periodontal diseases.
|
21035110 |
2011 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The interleukin-1 (IL-1) gene family has been associated with susceptibility to periodontal diseases, including aggressive periodontitis (AgP); however, the results are still conflicting.
|
20335539 |
2010 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hence, the relationship between IL-1 genotype and periodontal disease has been investigated by a number of studies.
|
20490394 |
2010 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Since IL-1 has been implicated in the pathogenesis of both BD and periodontal disease, we aimed to investigate the possible relation of the periodontal scores and SNPs of IL-1alpha-889C/T, IL-1beta-511C/T, and IL-1beta+3962T/C with BD compared to healthy controls (HC) and recurrent aphtous stomatitis (RAS).
|
17960403 |
2008 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There is a gene-environmental interaction because diabetic subjects bearing a variant IL-1 genotype C/T or T/T had an enhanced risk for periodontal disease in comparison with their IL-1 wild-type counterparts.
|
18315433 |
2008 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aims of the present study were to determine the distribution of IL-1 gene polymorphism (IL-1A+4845 and IL-1B+3954) and their association with periodontal disease severity and to determine the significance of detecting the composite genotype (IL-1A allele2+IL-1B allele2) versus detecting either of them alone.
|
16945028 |
2006 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
According to last years' research, polymorphism of IL-1 has an influence on the progression of periodontal disease.
|
17458052 |
2006 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aims of this retrospective study were to describe (1) the absolute failure rate of Brånemark System implants (Nobel Biocare AB, Göteborg, Sweden) consecutively installed over a 10-year period in partially edentulous patients treated for periodontal disease prior to implant treatment and under regular professional maintenance, (2) the rate of interleukin-1 (IL-1) polymorphism in those patients who experienced at least one implant failure during the first year of function, and (3) the prevalence of periodontal pathogens in dental and periimplant sites with and without signs of inflammation.
|
15903175 |
2005 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The low prevalence of some of the IL-1 gene polymorphisms in the ethnic groups included in this study limits the validity of conclusions on genotype associations with clinical findings, but there was a trend suggesting that allele 1 at IL-1B (-511) and IL-1B (+3954) was overrepresented among diabetics with periodontal disease.
|
14514232 |
2003 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Given the high prevalences of these polymorphisms observed in the general population,findings of the present study do not support a possible predictive value of the presence of allele 2 at IL-1A+4845 and IL-1B+3954 or the positive composite genotype for presence or absence of periodontal disease,in a Greek population.
|
12702109 |
2003 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
An increased risk of periodontal disease was found for IL-1 genotype-positive smokers: odds ratio adjusted for age, sex, education, and plaque OR = 2.50 (95% C.I.1.21 to 5.13; p = 0.013).
|
12598547 |
2003 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphism of IL-1 genes in these two loci may not be useful in predicting the severity of periodontal disease in the Thai ethnic group.
|
14974822 |
2003 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A genetic test for a composite interleukin-1 (IL-1) genotype is being marketed to predict risk for progression of periodontal disease.
|
12546098 |
2002 |