|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 and IL-33 are cytokines found to be implicated in many inflammatory disorders including rheumatoid arthritis, atherosclerosis and psoriasis.
|
30574739 |
2019 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study suggests that Stat3 activation in keratinocytes may impact on LC activation in situ via IL-1α stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23.
|
30514663 |
2019 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis.
|
31231388 |
2019 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.
|
31427775 |
2019 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis.
|
29535706 |
2018 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The compounds reported herein may have utility as lead compounds for the development of inhibitors of elastase-mediated activation of IL-36 and other IL-1 family cytokines in inflammatory conditions, such as psoriasis.
|
29744290 |
2018 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-1 family member IL-36α has proinflammatory and pathogenic properties in psoriasis.
|
28857172 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diacerein may have therapeutic applications to diminish IL-1-induced skin inflammation in psoriasis and attenuate IL-1-induced development of atherosclerosis.
|
28323859 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that mature IL-1α induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis.
|
28060905 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
PK2 promoted KC and macrophage to produce interleukin-1 (IL-1), the central player of inflammation and psoriasis, which acts on adjacent fibroblast to induce inflammatory cascades and KC hyperproliferation.
|
27887936 |
2016 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, changes in the expression of IL-1 receptors in psoriatic regulatory and effector T cells could contribute to the pathogenesis of psoriasis.
|
24665164 |
2014 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among LL37-inducible genes, IL-1 cluster genes, particularly IL36G, are of interest because we observed coordinate increases in CAMP and IL-36γ in the lesional skin of psoriasis, whereas virtually no CAMP or IL-36γ was observed in nonlesional skin and normal skin.
|
25305315 |
2014 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members.
|
23435685 |
2013 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1α, IL-6 and TNF-α expression levels were higher in patients with psoriasis.
|
21574971 |
2011 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.
|
21242515 |
2011 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidence indicates that IL-1 family members and Th17 cytokines have a pathogenic role in psoriasis.
|
21881584 |
2011 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the inflammatory milieu in the epidermal microenvironment in psoriasis is more likely dependent on evolutionarily ancient cytokines such as IL-1, rather than those of the adaptive immune response.
|
17591951 |
2007 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine what role the IL-1 system might contribute to the inflammatory process in psoriasis, semi-quantitative RT-PCR and cRNA microarray studies were performed on biopsies excised from lesional and non-lesional skin.
|
16460958 |
2006 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-1 gene complex may play a role in the development of PsA and/or psoriasis or act as a marker for other genes on chromosome 2q12 to 2q13.
|
12890860 |
2004 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are over 300,000 patients worldwide being treated with agents that specifically block the biological activities of interleukin-1 (IL-1) or tumor necrosis factor (TNF) for reducing the severity of autoimmune diseases such as rheumatoid arthritis, Crohn's disease or psoriasis.
|
12763679 |
2003 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that activation of MAPK by integrins, either directly or through increased IL-1alpha production, is responsible for epidermal hyperproliferation in psoriasis and wound healing, and that the sporadic phenotype of the transgenic mice may reflect the complex mechanisms by which IL-1 release and responsiveness are controlled in skin.
|
11518726 |
2001 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To thoroughly study the IL-1 system in psoriasis, we semiquantitatively analyzed the expression of all currently characterized IL-1 isoforms and their receptors in parallel in both lesional (PP) and nonlesional psoriatic (PN) epidermis.
|
9058835 |
1997 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, the expression of IL-1 and IL-6 mRNA was determined in cultured keratinocytes (KC) and fibroblasts from psoriasis skin.
|
2258628 |
1990 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The profound and complex changes in this system suggest IL-1 dysregulation may be integrally involved in the inflammatory, biochemical, and proliferative processes involved in the pathophysiology of psoriasis.
|
2191038 |
1990 |