|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO.
|
30997045 |
2019 |
|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunoreactivity of IL-1α and IL-1β was increased in Fra-2 TG mice and in patients with SSc.
|
31320452 |
2019 |
|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we aim to give a brief overview of IL-1 family cytokines and discuss their pivotal roles in the pathogenesis of SSc.
|
31572353 |
2019 |
|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?
|
29203183 |
2018 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Targeting IL-1 and its downstream IL-17 activity may be a novel treatment strategy for inhibiting inflammation and tissue fibrosis in SSc.
|
30042768 |
2018 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While meta-analysis showed there was no significant association between IL-1A -889C/T polymorphism and SSc, for IL-1B -511C/T (rs16944), significant associations were found in the comparison of allele C versus T (OR 1.267, 95 % CI 1.016-1.580) by combined different outcomes.
|
27098064 |
2016 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated SNPs of the IL-1 gene cluster in Iranian SSc patients.
|
26416393 |
2015 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of carbon-based nanoparticulate collected at the exhaust of newer (Euro 5) and older (Euro 4) diesel engines on SSc skin keratinocytes and fibroblasts were evaluated in vitro by assessing the mRNA expression of inflammatory cytokines (IL-1 α , IL-6, IL-8, and TNF-α) and fibroblast chemical mediators (metalloproteases 2, 3, 7, 9, and 12; collagen types I and III; VEGF).
|
24982919 |
2014 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MDR analysis showed a significant epistatic interaction among the interleukin-2 (IL-2) G-330T, IL-6 C-174G, and interferon-gamma AUTR5644T SNPs and the IL-1 receptor Cpst1970T, IL-6 Ant565G, and IL-10 C-819T SNPs in lcSSc and dcSSc susceptibility, respectively.
|
18576303 |
2008 |
|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epistatic interactions among IL-1 gene complex SNPs and clinical or environmental factors are more important than the singe attributes in the development of severe ventilatory restriction in SSc patients.
|
18396211 |
2008 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 78 patients with SSc [diffuse SSc (dcSSc), n = 31; limited SSc, (lcSSc), n = 47] and 692 healthy blood donors were genotyped for the following polymorphisms: IL10 T-3575A, IL10 A-1082G, IL1B C-31T, IL1B C-511T, IL1A C-889T, IL1RN A9589T, IL2 T-384G, LTA T-91G, and IL6 G-174C.
|
17444587 |
2007 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1 (IL-1) cluster gene single nucleotide polymorphisms (SNPs) were implicated in the pathogenesis of some interstitial lung diseases and may favor the progression of restrictive lung disease in SSc.
|
16636934 |
2007 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity.
|
17440718 |
2007 |
|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant differences in the luciferase activities were not detected between pGL3 (C/IL1A) and pGL3 (T/IL1A) in SSc fibroblasts.
|
17440718 |
2007 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because IL-1 production is regulated at the genetic level, we hypothesized that IL-1 gene complex single nucleotide polymorphisms (SNPs) might be relevant to the progression of ventilatory restriction in SSc.
|
17584583 |
2007 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The IL-1alpha-889 polymorphism, previously shown to predispose to increased IL-1 protein expression, may be involved in susceptibility to SSc.
|
14705223 |
2004 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts.
|
15468358 |
2004 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Interleukin 1alpha single-nucleotide polymorphism associated with systemic sclerosis.
|
14705223 |
2004 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Association of IL1A gene polymorphisms with susceptibility to and severity of systemic sclerosis in the Japanese population.
|
12528118 |
2003 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of constructs containing a series of 5' deletions of pLuc.-1437 revealed that the sequence between -96 and -82 (nuclear factor-interleukin-1 alpha [NF-IL-1 alpha]) was the most important for transcription of the IL1A gene in affected SSc fibroblasts.
|
12528119 |
2003 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Identification of an IL1A gene segment that determines aberrant constitutive expression of interleukin-1 alpha in systemic sclerosis.
|
12528119 |
2003 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of IL1A gene polymorphisms with susceptibility to and severity of systemic sclerosis in the Japanese population.
|
12528118 |
2003 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression.
|
12913118 |
2003 |
|
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-17 overproduction plays an important role in the pathogenesis of SSc, especially in the early stages of the disease, by inducing the proliferation of fibroblasts and the production of IL-1 and the expression of adhesion molecules on endothelial cells.
|
11083268 |
2000 |
|
Systemic Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The responses of procollagen alpha 1(I) mRNA to IL-1 and TGF-beta were lower in fibroblasts from SSc patients with early and mid-stage disease, but not in those from patients with-late stage disease, than in control fibroblasts, which indicates that these cytokines may be involved in the earlier phases of fibrosis in SSc.
|
9373715 |
1997 |