|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-1A (-889C/T) polymorphism is associated with the susceptibility of chronic periodontitis in African, European and American populations according to the currently available evidence.
|
31759990 |
2020 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between IL1A -889 and IL1B +3954 polymorphisms and chronic periodontitis is questionable due to methodological inconsistency.
|
30982982 |
2019 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The findings of the study show the significant association of IL1ß gene polymorphisms with CP increased susceptibility in combination of oral habits as mentioned earlier.
|
30676974 |
2019 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis.
|
30939298 |
2019 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A review of the literature was performed searching for the association of rs1800587 from Interleukin-1 alpha (IL1A) gene and rs1143634 from interleukin-1 beta (IL1B) gene with EARR and CP.
|
30142580 |
2018 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We will focus on inflammatory cytokines such as TNF-alpha, IL-1, and IL-6, because they have been shown to be increased in patients with chronic periodontitis, in patients with chronic systemic diseases, and in patients with both chronic periodontitis and other chronic diseases.
|
29065749 |
2018 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to test that hypothesis using functional Interleukin-1 (IL-1) gene variations across multiple ethnic populations to replace the non-functional markers originally associated with chronic adult periodontitis in Caucasians.
|
24690098 |
2015 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population.
|
26263533 |
2015 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objectives of this study were to determine the association between single nucleotide polymorphisms (SNPs) in IL1B (-511, +3954), IL1A (-889, +4845), and the variable number of tandem repeats (VNTRs) polymorphism in the IL-1RN gene with chronic periodontitis susceptibility and to analyze gene-gene interactions in a hospital-based sample population from South India.
|
25710474 |
2015 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest an association of genetic polymorphisms in the IL1-gene locus with risk for CP in patients with VD.
|
24612355 |
2014 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Positive genotype heterozygous of allele 1 and 2 for IL-1β+3954 and IL-1α-889 did not represent in this study a major risk for chronic periodontitis (p=0.590).
|
23241110 |
2013 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that genotype and protein production of IL-1α, IL-1β and IL-1RN are associated with CP in a Chinese population, and might be putative risk indicators for chronic periodontitis.
|
23592003 |
2013 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, current evidence showed that IL-1α -899 (+4845) C→T polymorphism probably increased the risk of CP.
|
24060296 |
2013 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the IL-1A (+4845) and/or IL-1B +3954 gene polymorphisms cannot be considered genetic markers of chronic PD.
|
22344672 |
2012 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A systematic review and meta-analysis was conducted in an attempt to clarify whether IL-1 gene variants were associated with well-defined clinical phenotypes of CP in white patients.
|
22348697 |
2012 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
neither IL1A (C-889T) nor IL1B (C+3954T) polymorphisms was associated with chronic PD.
|
20934174 |
2011 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The review concluded that there is currently limited evidence to implicate a specific IL-1 genotype as a risk factor for chronic periodontitis in white populations.
|
20490394 |
2010 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using random effect methods we found statistically significant association of IL-1A C[-889]T and IL-1B C[3953/4]T polymorphisms with chronic periodontal disease without any evidence of publication bias or significant statistical heterogeneity.
|
18673406 |
2008 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
While the association between the IL-1 polymorphisms and CP was confirmed, no association between the OPG polymorphisms and CP could be found.
|
17711477 |
2007 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) genes have been associated with an increased severity of chronic periodontitis.
|
17823082 |
2007 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While the association between the IL-1 polymorphisms and CP was confirmed, no association between the OPG polymorphisms and CP could be found.
|
17711477 |
2007 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL1A (-889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals.
|
17214636 |
2007 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Assessment of single nucleotide polymorphism at IL-1A+4845 and IL-1B+3954 as genetic susceptibility test for chronic periodontitis in Maharashtrian ethnicity.
|
16945028 |
2006 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Results of the present study reinforced the association of the IL-1 genotype as a risk factor for severe chronic periodontitis.
|
16945028 |
2006 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL-1 gene cluster have been associated with severe adult periodontitis.
|
16907768 |
2006 |