Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension.
|
27292124 |
2016 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Inflammation is a key event in hypertensive organ damage, and TNF-α and IL-1β are elevated in hypertension.
|
24877626 |
2014 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Chemokines such as C-C motif chemokine ligand 2 (CCL2), and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), are upregulated both peripherally and centrally in hypertension.
|
31427987 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In conclusion, no association of the IL1B C(- 31)T with HT was found, whereas combined frequency of the minor alleles of the IL1RN polymorphism was increased in the HT cohort studied.
|
11840488 |
2002 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The association between the number of IL1B C alleles and prevalence of hypertension was similar in univariate (OR 1.383; 95% CI 1.002-1.909; p = 0.048) and multivariate (OR 1.429; 95% CI 1.021-1.999; p = 0.036) analysis.
|
21840356 |
2011 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Whole blood HIF-1αgene expression, IL-1β geneexpression, and serumsuccinate levels were also significantly different in ADPKD patients with hypertension in comparison with normotensive ones (p < 0.05).
|
31319406 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Also, EGb761 inhibited hypertension with hypercholesterolemia-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1β in the kidney tissues.
|
28915536 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Prospective and retrospective cohort studies evaluating the association of circulating C reactive protein (CRP), high-sensitive CRP (hs-CRP), interleukin 6 (IL-6) and IL-1β to the risk of developing hypertension in the general population were included.
|
30700522 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In the real-world dataset, SDR-CR was capable of detecting a significant interaction between the IL-1α C-889T and the IL-1β C-511T single-nucleotide polymorphisms to predict the occurrence of restrictive lung disease vs. isolated pulmonary hypertension.
|
23153648 |
2013 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population.
|
17611547 |
2008 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To determine whether a clinically-utilised IL-1 receptor antagonist, anakinra, reduces renal inflammation, structural damage and blood pressure (BP) in mice with established hypertension.
|
27986554 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Here, we investigated the therapeutic effects of IL-1 receptor type I (IL-1R1) gene silencing in the PVN on hypertension.
|
29143938 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The TT genotype of IL-1B C-31T was associated with an increased risk of hypertension in all subjects (Odds Ratio [OR]=1.82, 95% Confidence Interval [95% CI]=1.09-3.06, compared with CC genotype).
|
19249142 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Study shows that IL-1 receptors can selectively decrease the oxygen arterial hypertension and influence the blood coagulation.
|
30672138 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We recently showed that hypertension is associated with increased dendritic cell production of the T<sub>H</sub>17 polarizing cytokines, IL-6, IL-1β, and IL-23.
|
27986660 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system.
|
15894892 |
2005 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Direct effects of IL-1 on pulmonary arterial smooth muscle cells (PASMCs) and parenchymal fibroblasts were investigated <i>in vitro</i>Fra-2 TG mice exhibited increased collagen deposition in the lung, restrictive lung function and enhanced muscularisation of the vasculature with concomitant pulmonary hypertension reminiscent of the changes in SSc patients.
|
31320452 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These studies demonstrate that circulating IL-1β, which increases in cardiovascular disorders such as hypertension and heart failure, acts on the SFO to increase inflammation and RAS activity in the SFO and PVN and that intervening in these neurochemical processes in the SFO can significantly reduce the sympathetic response.
|
29167166 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We examined the associations of hippocampal subfield volumes with age, a vascular risk factor (hypertension), and genetic polymorphisms associated with variation in pro-inflammatory cytokines levels (IL-1β C-511T and IL-6 C-174G) and risk for Alzheimer's disease (APOEε4) in healthy adult volunteers (N = 80; age = 22-82 years).
|
24947882 |
2015 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension.
|
21173343 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Chronic infusion of epigallocatechin-3-O-gallate into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation by restoring neurotransmitters and cytokines.
|
27659729 |
2016 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Here we find that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expression of IL-1β, who lack these characteristics.
|
28092664 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In addition, baicalin treatment attenuated hypertension-associated intestinal hyperpermeability and decreased the serum levels of inflammatory indicators such as high-sensitivity C-reactive protein (hs-CRP), interleukin 1 beta, and IL-6 in the SHRs.
|
31719823 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
For IL-1α and IL-1β, there was a significant stress-by-trimester interaction, while IL-10 was associated with a significant three-way interaction among stress level, hypertension status, and trimester.
|
30857409 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats.
|
27847271 |
2017 |