|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Excessive IL-1β production is a characteristic of most chronic inflammatory diseases, including atherosclerosis, type 2 diabetes, and obesity, which affect a large proportion of the global population.
|
30894604 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We further revealed that activated nod-like receptor protein 3 (NLRP3) inflammasome and its downstream products, i.e., IL-1 family members such as IL-1β and IL-18 were upregulated in the PVAT of obese mini pigs; PVAT dysfunction was also demonstrated in preadipocytes treated with palmitic acid.
|
30002491 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
The effect of chronic candesartan therapy on the metabolic profile and renal tissue cytokine levels in the obese Zucker rat.
|
20490358 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Metabolic immunomodulation involving IL-1 has been investigated for unfavorable metabolic effects, including obesity, but a potentially favorable role for IL-1 remains unclear.
|
29791847 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conclude that obesity leads to the airway hyperresponsiveness preventable by caloric restriction and IL-1β blockade.
|
30670753 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These novel findings suggest that dietary MUFA can attenuate IL-1β-mediated insulin resistance and adipose dysfunction despite obesity via the preservation of AMPK activity.
|
25626736 |
2015 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that obesity (P < 0.01), obesity-associated T2D (P < 0.01) and NAFLD (P < 0.05) increased the expression of different components of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.
|
31551515 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Higher rates of esophageal cancer cases may be attributed to lifestyle factors such as: diet, obesity, alcohol and tobacco use.Moreover, the presence of oral <i>P. gingivalis</i> and <i>T. forsythia</i> has been found to be associated with an increased risk of esophageal cancer.Our review describes the role of <i>P. gingivalis</i> and <i>T. forsythia</i> in signaling pathways responsible for cancer development.It has been shown that <i>T. forsythia</i> may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α.Moreover, gingipain K produced by <i>P. gingivalis,</i> affects hosts immune system by degradation of immunoglobulins and complement system (C3 and C5 components).
|
30728854 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In contrast, obese patients diagnosed with anxiety or mood disorders only showed significantly lower expression levels of IL1B in VAT and ADIPOQ in SAT when compared with obese subjects without mental disorders.
|
30504920 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The pyrogenic property being the first activity described, members of the interleukin-1 superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are now known to be involved in several inflammatory diseases such as obesity, atherosclerosis, cancer, viral and parasite infections, and auto-inflammatory syndromes as well as liver diseases.
|
31507607 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes.
|
31191559 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our present findings indicate that elucidating the IL-1β mediated homeostatic control mechanisms in the cingulate cortex may lead to the better understanding not only the regulatory entities of the healthy organism but also those found in obesity, diabetes mellitus and other worldwide rapidly spreading feeding-metabolic disorders.
|
28527691 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interestingly, IL-1β which is associated to several steps in the development of atherosclerosis, heart disease, and the association of obesity and type II diabetes with CVD, is activated by the inflammasome complex, a multiprotein complex composed of an intracellular sensor, typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC (apoptosis-associated speck-like protein containing a CARD.
|
29588192 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels.
|
28324042 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, the administration of IL-1 receptor antagonist to obese mice markedly reduced obesity-induced steatosis and hepatic lipogenic gene expression.
|
25216251 |
2014 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The decrease in IL-1 receptor antagonist expression after weight loss and the strong correlation between the decrease in IL1B expression and the increase in insulin sensitivity suggest a contribution of these genes to insulin-resistant states found in obesity and the metabolic syndrome.
|
18191048 |
2008 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa).
|
28659656 |
2017 |