|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To analyze the reported association of IL1RN polymorphisms with response to IL-1 blockade in a German cohort of patients with systemic idiopathic arthritis (SJIA) and to assess other factors on treatment response.
|
31599092 |
2020 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The degree of secondary joint swelling and arthritis index, expression of miR-26a, pathological changes, proliferation and apoptosis of chondrocytes, and expression of CTGF, interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α, Bax, and Bcl-2 were also determined through a series of experiments.
|
31267533 |
2020 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Painful (mechanical and thermal hypersensitivity, ongoing pain and arthritis score) and inflammatory (oedema, plasma extravasation, cell infiltration and IL-1β release) parameters were assessed several hours after intra-articular injection of MSU (100 µg/articulation) in wild-type or knockout mice for Toll-like receptor 4 (TLR4), inducible nitric oxide synthase (iNOS), transient receptor potential (TRP) V1 and the IL-1 receptor (IL-1R).
|
31298290 |
2020 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, treatment with IL-1 antagonists effectively lowered the proportions of NCR<sup>+</sup> ILC3s and IL-17A producing ILC3s in Ncf1<sup>-/-</sup> arthritic mice and ameliorated the joint inflammation.
|
31350760 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study provides evidence that IL-1β combined with IL-17A promoted chronic inflammatory arthritis by activating the catabolic processes accompanied with the suppression of cartilage anabolism.
|
31614911 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1β-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).
|
31764352 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The anti-inflammatory effects of JC3 were investigated in vitro using interleukin-1beta (IL-1β)-stimulated fibroblast-like synoviocytes (FLS) derived from arthritis patients.
|
30565030 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
NFIL3 mutation can sensitise for arthritis development, in mice and humans, and rewires the innate immune system for IL-1β over-production.
|
30552177 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, treatment with kaempferitrin decreased paw thickness and arthritis scores, and reduced the serum levels of IL-1β, IL-6, and TNF-α in a collagen-induced arthritis mouse model.
|
31155798 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13.
|
30691120 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that TOV has significant anti-arthritic effects on collagen-induced arthritis in rats, which may be attributed to the inhibition of the levels of IL-1β, IL-6, IL-8, IL-17A, TNF-α, MMP-3 and MMP-9, and the increase of IL-10 in serum as well as down-regulation of the protein expression of COX-2 and iNOS in synovial tissues via suppressing the phosphorylation and degradation of IκB.
|
30831463 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the one hand, microinjection of ORAI1 overexpressed vector in sick toe partly counteracted the therapeutic effects of resveratrol on adjuvant arthritis and serum inflammatory cytokine including IL-1, IL-6, IL-8, IL-10 and TNF-α.
|
31426853 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The levels of PGE2, TNF-α, and IL-1β in serum of AIA rats were detected by enzyme linked immunosorbent assay (ELISA) to explore its mechanisms.
|
30471320 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we describe two different acute inflammatory monoarticular arthritis models (mBSA/IL1β and mBSA/GM-CSF) providing a more rapid and potentially simplified approach to investigate the pathogenesis.
|
29761402 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our work demonstrated that EEC possessed the potential therapeutic effect against arthritis in rodents which was attributed to modulating proinflammatory cytokines TNF-α, IL-1β and anti-inflammatory factors IL-10.
|
29753098 |
2018 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Dex-Lips effectively suppressed the joint swelling in arthritis rats and significantly down-regulated serum pro-inflammatory cytokines including tumor necrosis factor-α and interleukin-1β when compared to free dexamethasone.
|
29408684 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we investigated the role of inflammasomes and their effectors, including interleukin-1 (IL-1), IL-18, and pyroptosis, on inflammation and control of infection during <i>Brucella</i>-induced arthritis.
|
29941463 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis.
|
28645307 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although antibody responses generated to one variant were potently inhibiting IL-1β, antibody responses induced by the other variant even potentiated the in vivo effects of IL-1β; the latter led to enhanced morbidity in 2 different IL-1β-mediated mouse models, including a model of inflammatory bowel disease and an inflammatory arthritis model.
|
27833025 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The therapeutic efficacy was studied in CIA (collagen-induced arthritis) mice, which were administrated with either FL-BsAb1/17 (IgG-like bispecific antibody targeting IL-1β and IL-17A) or monovalent IL-1β Mab or IL-17A Mab (anti-IL-1β/IL-17A monoclonal antibody).
|
28249243 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α).
|
28457885 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transfer of WT but not IL-1-deficient megakaryocytes restored arthritis susceptibility to KitW/Wv mice.
|
28375155 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Arthritis was induced in male C57BL/6 mice with mBSA/IL-1β.
|
28587618 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SF from patients with non-inflammatory arthritis, that is patients with osteoarthritis (OA), did not affect the IL-1β production but slightly enhanced the secretion of IL-8.
|
27206713 |
2016 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that ROS act as a negative feedback to constrain IL-1β-mediated inflammation, accounting for the more severe arthritis in the absence of NOX2.
|
25867281 |
2015 |