|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
AIEC infection led to an increase of pro-inflammatory cytokines IL-1β (<i>p</i> < 0.0001) and TNF-α (<i>p</i> < 0.0001) in CD macrophages.
|
31694333 |
2019 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, GSK2256294 reduced IL4 and IFNγ in ulcerative colitis, and IL1β in Crohn's disease specifically, suggesting potential differential effects of GSK2256294 in these two diseases.
|
31002701 |
2019 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human macrophages with the Crohn's disease-associated Atg16l1 variant T300A exhibited more production of IFN-β and IL-1β.
|
29358708 |
2018 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
SHIP<sup>-/-</sup> Mϕs drive Crohn's disease-like intestinal inflammation and fibrosis, which is dependent on heightened responses to innate immune stimuli generating IL-1, and IL-4 inducing abundant arginase I.
|
29345374 |
2018 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, while both studies of murine models of gut disease and patients provide data that the main cytokine product generated by this inflammasome, IL-1β, does in fact contribute to inflammation in IBD, there is no evidence that IL-1β plays a decisive or prominent role in "ordinary" patients with IBD (Crohn's disease).
|
30455704 |
2018 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1β levels were significantly higher in CD patents in comparison with controls (p = 0.032).
|
28523573 |
2017 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-α, IL-6, IL-1β, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn's disease (CD) patients.
|
28452812 |
2017 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strategies to reduce IL1B might be developed to treat patients with CD found to have low SHIP activity.
|
26481854 |
2016 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role in plaque psoriasis, we analyzed the involvement of IL-17C and IL-36γ in anti-TNF-induced skin lesions of patients with Crohn's disease.
|
25299544 |
2014 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Invasiveness of intracellular E. coli strains into the intestinal mucosa and IL-1β production may contribute to CD and UC pathogenesis.
|
24581881 |
2014 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of tumor necrosis factor-α-α and interleukin-1β increased after adenosine-triphosphate and decreased after KN62 treatment in CD.
|
24412990 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Serial serum concentrations of TNF and IL1β and TNF promoter region and IL1B polymorphisms were determined in 47 patients (29 CD and 18 UC) receiving infliximab and correlated with treatment response.
|
22960943 |
2013 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-1β (IL-1β) has been shown to play an essential role in mediating intestinal inflammation of Crohn's disease and other inflammatory conditions of the gut.
|
22817402 |
2012 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study is the first to link the ATG16L1 polymorphism with an excessive production of IL-1β and IL-6 in humans, which may explain the effects of this polymorphism on the inflammatory process in Crohn's disease.
|
21406388 |
2011 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs3024505 marker polymorphism flanking the IL-10 gene was significantly associated with risk of UC and CD, whereas no association was found between IL-1 beta or HO-1 gene polymorphisms and risk of CD and UC in this Danish study, suggesting that IL-10, but not IL-1 beta or HO-1, has a role in IBD etiology in this population.
|
20509889 |
2010 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-alpha and IL-1 have been associated with mucosal inflammation in both Crohn's disease (CD) and ulcerative colitis (UC).
|
18942751 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with Crohn's disease, trauma to rectum, ileum, or skin led to abnormally low neutrophil accumulation (differences from healthy individuals of 79%, n=8, p=0.0003; 57%, n=3, p=0.05; 50%, n=13, p<0.0001, respectively) and lower production of proinflammatory interleukin 8 (63%, n=7, p=0.003; 63%, n=3, p=0.05; 45%, n=8, p<0.0001) and interleukin 1beta (50%, n=8, p=0.0005).
|
16503465 |
2006 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the association of polymorphisms in the CARD15, TNFA, IL1B, and IL1RN genes with risk of development of CD and with the clinicopathological profile of CD patients.
|
15803022 |
2005 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS.
|
12468823 |
2002 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ninety-six patients with ulcerative colitis (UC), 98 patients with Crohn's disease (CD), and 132 ethnically matched healty individuals (HC) were typed for the polymorphic sites in the promoter region (position -511) and in exon 5 (position +3953) of the IL1B gene, using polymerase chain reaction (PCR)-based methods.
|
10380697 |
1999 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data support the concept that CD and severe UC have a genetic disequilibrium in the distribution of IL1B and IL1RA gene polymorphisms.
|
10192196 |
1999 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 alpha and IL-1 beta were significantly increased in inflamed mucosa in inflammatory bowel disease (IBD) (CD: 53.5 (22.4) and 409.9 (118.7) pg/mg protein, respectively; UC: 18.9 (6.8) and 214.5 (78.2) pg/mg, respectively) and non-IBD patients (19.2 (7.4) and 281.4 (121.0) pg/mg, respectively; p < 0.0001) compared with normal controls (2.8 (0.6) and 30.6 (5.6) pg/mg, respectively).
|
9414973 |
1997 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Significantly higher levels of IL-1 beta mRNA were found in uninvolved mucosa from CD patients who presented with a relapse of disease activity, as compared to newly diagnosed cases with histological features of CD at an early stage.
|
9246063 |
1997 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This article will review current progress in understanding the role of Il-1 and Il-1ra in IBD, as well as discuss recently described polymorphisms in the Il-1 gene cluster and their association with UC and CD.
|
8899101 |
1996 |